Background: Good career choice outcomes should produce a series of positions that give opportunity for good performance, maintain a commitment to the field, and provide high work satisfaction. Aim: to investigate factors contributing to career change among nursing staff. Research design: A descriptive research design was utilized to fulfill the aim of the study. Subjects: a convenience sample of staff nurses their age under 40 years working at Minia University and Fever Hospitals during the period of data collection. Setting: Fever Hospital and Minia university hospital in Minia city, Egypt. Data collection tools included three tools; first personal factors, second, anticipated career change factors, and third, social factors. Results: 82.0%, 80.5%, 77.3, and 52.3% of the studied nurses have moderate total anticipated factors, job satisfaction, burnout level, and autonomy, respectively, while 64.1%, 41.4%, 21.1%, 18.0%, 14.8% of them had high-level workload, autonomy, burnout, anticipated factors, and job satisfaction respectively. Moreover, 53.1% of the studied nurses have moderate social factors to career change, 44.5% have high levels, and 2.3% have low levels. Conclusion: This study revealed that nearly two-thirds of the studied nurses mentioned the main factors for career change were workload and social factors. Recommendation: develop advanced career ladder for better advancement, high job satisfaction, autonomy and low burnout and career change.