Background: Drugs abuse a very big problem in the world today and it is ruining the lives of many millions of people both in adolescent and general population. The use of illegal drugs has spread at a high rate and has penetrated every part of the world. No nation has been spared from the devastating problem caused by drugs and substance abuse.Aim of this study is to assess knowledge and attitude of secondary school students regarding drug abuse at Minia City. Study design: Descriptive research design was utilized in this study. Subject: 400 students from High Secondary Schools and Technician Schools. Setting: The study was conducted in Minia City Secondary Schools.  Tools: Two tools were utilized in this study, the first tool was an interviewing structured questionnaire sheet was contained two parts: Part 1: Socio-demographic characteristics about student's. Part II: Secondary school students' knowledge regarding drug abuse second tool Secondary school students' attitudes regarding drug abuse.   Results: The results show that 78% of students in secondary have poor knowledge scores and 50 % of students in technical school have poor knowledge score regarding drug abuse, the mean score of students' knowledge was 5.9±2.3, also 75% of secondary students have positive attitudes and 62% of technical students have negative attitudes with mean attitudes score of study subjects is [16.7±5.4. Conclusion: the majority of students in Secondary School have poor knowledge scores, while half of students in Technical School have poor knowledge score, moreover three quarters of Secondary School students have positive attitudes while less two thirds of Technical School students have negative attitudes. Recommendations: Increase  students awareness through social media and network regarding drug abuse, and educational programs for the Secondary and Technician Schools personnel (teachers and social workers), regarding understanding of student drug abuse concept and proper handling of such cases.