Background: Modified ventilator bundle is a cluster of key interventions deriving from evidence-based clinical practice guidelines that when implemented together are expected to improve patient outcomes and reduced the risk of ventilator associated pneumonia and other related complications common in ventilated patients. Aim: The current study aimed to apply a modified ventilator bundle and evaluate its effect on weaning among mechanically ventilated patients. Design: A quasi- experimental research design was utilized. Setting: This study was conducted at the following critical care units (surgical, medical and cardiac care unites) affiliated to Bani Suief University Hospital in Bani Suief city, Egypt. Subjects: A Purposive sample of 100 mechanically ventilated patients divided into two groups, the study group included patients who received the modified ventilator bundle while the control group included patients who received the routine hospital nursing care. Data collection tools: Two tools were used; First tool patient assessment sheet include two parts, part one: patient demographic and medical characteristic part two:  physical assessment record. Second tool: Weaning process assessment checklists by used burns wean assessment program score. Results: The study group of patients obtained higher weaning scores than the control group. As well the study group demonstrated shorter duration of the connection to mechanical ventilation compared to control group. Conclusion: Implementation of modified bundle plays a pivotal role on higher weaning score and reduction of ventilation days. Recommendations: Designing in-service training educational program for critical care nurses to improve nurses' knowledge and practice regarding a modified ventilator bundle. Furthermore, replication of the study on a larger probability sample from different geographical locations in order to generalize the results.