Background: Electronic Health Information System (EHIS) are currently considered a major part of the healthcare system; this importance emerges from the importance of their role in managing all patient data to documenting all medical services. Aim to evaluate the effectiveness of health care providers' usage of Electronic Health Record at Al-Rajhy Assiut University Hospital for Liver. Research design; Descriptive comparative research design was used for this study. Setting; the study had been conducted- at Al-Rajhy Assiut University Hospital for Liver. Subjects; the study subject included all users of the EHRs, (n= 250) Tools; one tool consists of three parts asfollowing; personal and professional  characteristics data sheet, Evaluation of electronic health records sheet, and Utility of electronic hospital information system sheet. Results; the study finding revealed that the majority of studied  subjects wereagreed that the system works well, easy to input information into electronic records, and easy to use, most of them agreed that the system provides clear, useful, complete information, provides reliable information, records are useful, present updated information in an appropriate format. And more than half of them agreed that the records offer reliability, and moreover facilitates coordination of tasks, decision process, auditing and release of procedures, facilitates analysis of hospital bills, verification of the materials & medications used in units, and facilitates hospital billing. Conclusion; There were high statistical significant difference among physicians, nurses, and employees' regarding to evaluation of electronic records system.There were statistical significant differences among physicians, nurses, and employees and general utility of electronic records. Recommendation; guideline and manual book about how to use of Health Information System should be available for users to support them in documentations. Arrange a training program to assess awareness for HIS users regarding the benefits of Information Technology and HIS. Training should be assured by arranging workshops to improve their computer and HIS proficiency.