Background: Patient with schizophrenia usually has lack of social skills and has an inability to communicate effectively with people, so that social competence program is needed for schizophrenic patients to improve their self-esteem and assertiveness skills .This study aimed to assess the effect of social competence program on self-esteem and assertiveness among schizophrenic patients Quasi experimental research design was utilized in this study .The study sample  included 100 patients ,The study included four tools (I) structured Interview questionnaire to assess sociodemographic and clinical characteristics, tool (II) Rosenberg Self – Esteem Scale to assess level of self-esteem tool (III) Rathus Assertiveness Schedule to assess level of assertive behavior and tool (IV) Brief psychiatric rating scale to assess psychiatric symptoms. The result demonstrated that there were an improvement in total mean scores of self-esteem, assertiveness and psychiatric symptoms in post implementation as compared to its pre program implementation and follow up program implementation. Also the study showed that there, was statistically significant negative correlation between self-esteem and assertiveness among Schizophrenic Patients. It was concluded that there was highly statistically significant different in self-esteem, assertiveness and psychiatric symptoms after implementation of the program and in follow up assessment. The study recommended that collaboration between all health team members to develop specific goals for behavior modification, improving assertiveness and increasing patient's socialization.