Osteoporosis is a metabolic bone disease, negatively affects all living activities of the individual, movement notably and causes fractures, pain and body image changes. (Ozturk and Sendir 2011). The aim of the study: To assess knowledge and self-efficacy regarding osteoporosis prevention among multiparous women based on health belief model. Research design: The study was carried out using a cross sectional descriptive research design at Maternal and child Health centers (MCH) at Minia City. Sample: A convenient sample of 196 multiparous women was selected. Data collection Tools: The first tool is an osteoporosis multiparous personal data questionnaire included questions related to demographic characteristics, obstetric history, personal history. The second tool is an osteoporosis knowledge assessment questionnaire to assess osteoporosis knowledge. The third tool is an osteoporosis health belief scale to measure health beliefs regarding osteoporosis. The fourth tool is an osteoporosis self-efficacy scale. Results: Forty nine and half percent of Multiparous women their age ranged from 30-35 years. More than half of multiparous women have fair level knowledge about osteoporosis with a mean 8.25 ± 3.74. in addition to 53.6% of multiparous women their perception of susceptibility reveals low, regarding severity perception reveals that 61.2% are low,  regarding total health belief reveals that, 65.3% have high score positive perception with a mean score   94.71 ± 25.26. More than half of multiparous women have low self-efficacy with a mean score 36.53 ± 12.119. There is statistically significant correlation between osteoporosis self-efficacy and osteoporosis health belief. Conclusion: there was fair level Knowledge about osteoporosis, good belief about calcium intake and low self-efficacy among the majority of the multiparous women. Recommendations: It was recommended that the need of setting up of health education programs regarding osteoporosis among multiparous women .