Aim: This study aimed  to evaluate  the   effect   of  multimodal   preparation   package   on   patients`  needs  and  satisfaction  with  bone  marrow transplantation  .  Subjects and Method: A quasi-experimental design was utilized for the conduction of this study in the Bone Marrow Transplantation Unite and   Outpatients` Clinics at Nasser Institute Hospital. A purposive sample composed of 70 adults and old age patients, from both genders undergoing bone marrow transplantation were recruited from the above mentioned settings. Tools : 1) Patients'  needs assessment sheet  (pre / post and  follow- up   tests )  to assess  studied  patients' health  needs : physical  , psychological  , social , spiritual  and  educational   .  2) Patients` satisfaction   assessment   sheet  ( post  test  ) to assess  the  satisfaction  level  .  Results:  More than three fifths of the studied patients   had the age   of 18 - <35 yrs.  and   were   male  .  The   health   needs   were    higher   in pre  test   added  to  elevated   anxiety ,  pain  and fatigue  levels  . Conclusion: The current study concluded that, the   multimodal   preparation  package   had a positive effect on  meeting  the  health needs  ( physical, social, psychological, spiritual  and educational  ) , added to significant  improvement  of  satisfaction  level   in  post  test  among the studied patients  undergoing   bone  marrow  transplantation  procedure   .  Recommendations: Further studies should be carried out on a large number of such groups of patients for   supporting of   the results and generalization   .