Background: Non-adherence in patients with schizophrenia is associated with increased hospitalization, higher health care costs and poor long-term outcomes in terms of relapse rates, and suicide attempts. So, this study aimed to assess drug attitude, and medication adherence behavior among schizophrenic patients. Design: A descriptive correlational research design was used in this study. The study sample included 50 male and female schizophrenic patients admitted to the psychiatric inpatient unit of Minia Hospital for Mental Health and addiction treatment. Data were collected through Personal demographic and clinical data sheet, drug attitude inventory scale, and medication adherence behavior tool. Results: it was found that more than half of the studied sample were males, unemployed, while nearly half of them were  in age group ranged from 28 <38 years old and married. Regarding drug attitude, this study revealed that, more than three quarters of the studied sample had poor attitude toward drug. In relation to medication adherence behavior, about three quarters of the studied sample had poor adherence .Conclusion: highest percentage of the studied sample had poor attitude toward antipsychotic drug and poor medication adherence behavior. Recommendation: structured psychoeducational program should be developed for schizophrenic patients and their families to improve knowledge about schizophrenia and medication adherence in order to prevent relapse and rehospitalization.