Background Women spend over one‑third of their life in postmenopausal period Regarding this issue, considering the quality of life for women in postmenopausal period , The aim of this study was to evaluate the effect of self care guidelines on the quality of  life among women with menopausal symptoms. The quasi-experimental Design(time series design) was conducted in Obstetrics and Gynecology hospital in Elminia city. The purposive sample technique was used to recruit one hundred of menopausal women Tools Interviewing sheet,  Menopause specific quality of life questionnaire (MENQOL). Results of the study illustrated that there were a strong association  between severity of menopausal symptoms as "vasomotor, somatic, , psychosomatic,  urogenital symptoms" and lower level of QOL during the menopausal period. There were a significant differences  between Pre and post intervention regarding total mean score of  quality of life of the menopausal women The study concluded that guideline is an effective complementary health approach for improving quality of life in menopausal women. Recommendations  Self-care guideline should be used in health care centers as a routine care for menopausal women.