Background: Addiction is a major problem in Egypt, due to the rapidly growing and changing patterns of substance use considering its effect on quality of life. Aim of the study was to assess Quality of Life (QoL) and Coping Strategies among addict patients and the relationship between them. A descriptive correlational design was used in this study. This study was conducted at Minia Psychiatric Health and Addiction Hospital in Inpatient Unit and Outpatient Clinic. Four tools were used to measure the variables of this study. This included Personal & Medical data tool, Drug Abuse Screening Test (DAST-20), Short Form -36 Health Related Quality of Life questionnaire (SF-36) and Cope Inventory. The study sample comprised of 100 drug addict patients whose age ranged between >19 and 54 years. The main results of this study revealed that, total mean score of the Quality of Life was 58.02±16.3 which indicated poor Quality of Life and the mean score of Coping Strategies was 119.4±216 which also indicates moderate use of effective coping. There were significant negative correlations among Drug Abuse Screening Test and Quality of Life and Coping Strategies among addict patients. There was a significant positive correlation between QoL and Coping Strategies among patients. A psycho educational program is recommended to help drug addict patients cope effectively with stress and improve their quality of life.