Little is known about the role of maternal oral health and its potential impact on the health of pregnant women. This study aimed to assess knowledge, attitude and practices of women regarding oral and dental healthcare during pregnancy. A cross-sectional descriptive research design was adopted for this study. This study was conducted at MCH centers in Minia city (first child health center MCH center and west MCH center).  A purposive sample of 300 pregnant women who had not any medical disorder was included in this study. Data were collected through four tools:  Structured interviewing questionnaire, Knowledge Questionnaire sheet, women's attitude by the likert scale, and women's self-practices assessment tool, the study revealed that large proportion of pregnant women had poor knowledge, more than half of them had positive attitude about oral health, and more than half of them had poor practice regarding oral health care during pregnancy. The study concluded that there was lack of oral health knowledge and practices related to oral and dental healthcare among pregnant women.  The study recommended that health education & awareness and stress on follow up programs should be carried out during pregnancy in order to motivate and educate pregnant women about importance of good oral health; further researches are needed to investigate the effect of bad oral care on pregnancy outcome