Background: Stomatitis accompanied with receiving chemotherapy occur approximately 40% among all patients. The onset of starting stomatitis among patients receiving chemotherapy around days four to five day from starting chemotherapy with a peak on the 7th -14th day after chemotherapy. Aim of the study: to evaluate impact of using pure natural honey as a topical application for patients who receiving chemotherapy regimens on reducing risk of stomatitis.  Research design: Quasi-experimental research design was utilized in the current study. Subjects: A purposive sample including (60) male and female adult patients were included in the current study. Setting: This study was carried out at oncology center in Minia city in chemotherapy outpatient clinic, inpatient and outpatient chemotherapy department. Tools of data collection: Three tools were utilized to collect data: 1- Patient's biosociodemographic characteristic: structured interview tool; 2- Beck Oral Assessment Scale (BOAS); 3- oral toxicity Scale. Results: There was a highly statistical significant difference regard beck oral assessment manifestations between study and control groups during third observation for them post first session of chemotherapy. Also, there was a highly statistical significant difference among same groups during three observations post second and third session of chemotherapy. Results illustrate that the percentage of oral stomatitis degree occurs among study group in three sessions were (0.0%, 3.3%, 6.7%) in the three observations respectively. Conclusion: Honey was an effective in preventing and decreasing oral stomatitis and gingivitis in patients receiving chemotherapy. Recommendations: Regular training programs to keep nurses in oncology unit updated with the most recent strategy for oral hygiene that promote oral wellness.