Infections of Urinary tract are one of the significant to recommending antibiotic utilization. To involve the most perfect antibiotic for treatment patients, solid and ongoing information about the study of disease transmission and antibiotic resistance of pathogenic bacteria should be accessible for clinicians. So, the normal checking in every nation is required. The points of our review to explore the uropathogenic bacterial variety and antibiotics resistance rates of pathogenic bacteria at the Mansoura Oncology Center (Egypt, Mansoura city) from first October, 2019 to 30th September, 2020 and furthermore to add to checking and topographical variation of treatment by antibiotic. 150 urine samples by aretrospective analysis at Mansoura Oncology Center was processed according to the perfect protocol of urine analysis. Current results were prepared to obtain the prevalence of Urinary tract infections, antibiotics bacterial resistance, time over evolution, and multidrug resistance rate. Bacteria collected from 100 samples were the Escherichia coli and Klebsiella pneumoniae were to be the most identified with 42.0%, and 35.0% respectively. Other main detected species were Enterococci (9%), Pseudomonas (5%), Proteus mirabilis (4%), Citrobacter (2%), Breundimona (1%), Raoultella (1%), and Kluyvera cryocre-scens (1%). Resistance tests to antibiotics indicated K. pneumoniae was more resistance to Cefotriaxon 39.3%, while E. coli was resistant to Ciprofloxacin and Levofloxacin by 41.8%. The variety of some uropathogenic bacteria acquired had all the reserves of being resistant to various antibiotics. Ready faciing by arestorative impasse and the coming of bacteria with multi-resistant, recognizing explicit causes also is significant to adjust antibiotic treatment.