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195001

Neutrophils to lymphocytes and platelets to lymphocytes ratios in patients with chronic hepatitis B virus

Article

Last updated: 28 Dec 2024

Subjects

-

Tags

Biochemistry

Abstract

Systemic liver inflammation occurs as the result of liver injury. This can be cause by hepatitis B virus (HBV) infection. Whether neutrophils to lymphocytes ratio (NLR) and platelets to lymphocytes ratio (PLR) are capable to be included as systemic inflammatory markers or not will be investigated. Their correlations with liver function tests and with viral DNA were also tested in patients with chronic hepatitis B (CHB).Patients and Methods: Blood sample were taken from patients (n=42) and from the healthy control (n=20).HBV-DNA, hepatitis B surface antigen (HBsAg), total white blood cells count as well as neutrophils, lymphocytes and platelets were done for each individual. Also, liver function tests were estimated. Results: The platelets counts in the blood of patients was significantly decreased when compared with that of the healthy control (P<0.002).The percentage of neutrophil was also decreased in patients when compare with the control value. Such percent was not significant (P<0.837). Further, the percentage of lymphocyte was not significantly increased in the blood of patients when compare with the healthy control value (P<0.72). Taken together, the NLR and PLR were decreased in patients when compare with the healthy control values but such decreases were not significant (P<0.89 and 0.28, respectively). PLR was significantly and positively correlated with ALT and viral DNA (P<0.02, P<0.04, respectively). Conclusion: NLR and PLR, as systemic inflammatory markers cannot be used as indicators for the presence of liver inflammation in chronic hepatitis B (CHB) patients. In spite, such chronicity can only reduce platelets and lymphocytic counts.

DOI

10.21608/sjdfs.2020.195001

Keywords

HBV. HBV-DNA, NLR, PLR

Authors

First Name

Gamal

Last Name

Shiha

MiddleName

E.

Affiliation

Department of Internal Medicine, Faculty of Medicine, Mansoura University and Egyptian Liver Hospital

Email

g_shiha@hotmail.com

City

-

Orcid

-

First Name

EL-Shahat

Last Name

Toson

MiddleName

-

Affiliation

Chemistry Department, Faculty of Science, Damietta University, New Damietta City, Egypt

Email

-

City

-

Orcid

-

First Name

Ryham

Last Name

EL-Sawah

MiddleName

M.

Affiliation

Chemistry Department, Faculty of Science, Damietta University, New Damietta City, Egypt.

Email

reham.magdy.sawah@gmail.com

City

-

Orcid

-

Volume

10

Article Issue

1

Related Issue

27643

Issue Date

2020-12-01

Receive Date

2021-09-18

Publish Date

2020-12-01

Page Start

73

Page End

79

Print ISSN

2314-8594

Online ISSN

2314-8616

Link

https://sjdfs.journals.ekb.eg/article_195001.html

Detail API

https://sjdfs.journals.ekb.eg/service?article_code=195001

Order

195,001

Type

Original articles

Type Code

2,045

Publication Type

Journal

Publication Title

Scientific Journal for Damietta Faculty of Science

Publication Link

https://sjdfs.journals.ekb.eg/

MainTitle

Neutrophils to lymphocytes and platelets to lymphocytes ratios in patients with chronic hepatitis B virus

Details

Type

Article

Created At

23 Jan 2023