The present study was conducted to demonstrate the histological effects of ribavirin and/or sofosbuvir on liver and kidney of rats. Rats were treated with ribavirin (0.0227 mg/kg body weight), sofosbuvir (0.01 mg/kg body weight) and mixture of ribavirin and sofosbuvir for 12 weeks. Liver and kidney were stained with H/E stain. Liver tissue also stained with AgNORs stain. The results showed that no histological alteration or abnormal counts were observed after treatment with ribavirin and / or sofosbuvir. Also the count of AgNORs is non-significantly differs between the normal non-treated rats and those treated with ribavirin and/or sofosbuvir. The present study concluded that, treatment with ribavirin and / or sofosbuvir or both has no side effects on normal rats.