The present study aimed to investigate changes of some oxidative stress biomarkers in Egyptian patients infected with schistosoma or/and hepatitis C virus (HCV). Regarding to oxidative stress markers, catalase was significantly higher in HCV- patients group and HCV & Schistosoma infected group compared to Schistosoma infected group. Glutathione peroxidase was significantly higher in all patient groups. Superoxide dismutase was significantly higher in HCV group, as well as HCV & Schistosoma infected patients. Non-significant changes were observed with superoxide dismutase in Schistosoma infected group. Nitric oxide was significantly higher in all patient groups. Catalase, glutathione peroxidase , nitric oxide, and superoxide dismutase levels might be used as monitoring markers for oxidative stress in Schistosoma infection or/and HCV carrier cases.