ManageChatDiscover
281033

Can Neutrophil to Lymphocyte Ratio, Platelet to Lymphocyte Ratio and Tumor Necrosis Factor Alpha Predict Lupus Nephritis Flares?

Article

Last updated: 05 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

Diagnostics

Abstract

Background: Systemic Lupus Erythematosus (SLE) is a chronic autoimmune multisystem disease with an array of variable presentations in which the kidney is the most affected organ and influences the overall outcome of the patients. Methodology: The study is a case control study conducted on 90 SLE patients diagnosed according to ACR criteria grouped into three subgroups. It aims at evaluating the role of serum tumor necrosis factor alpha (TNFα), neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) in diagnosing renal flares and predicting the prognosis in lupus nephritis patients. Results: A highly significant difference was observed between both the SLE starting dialysis group, the SLE nephritis ( LN ) group, and the control group regarding neutrophil to lymphocyte ratio and TNFα (p<0.001 & ˂0.001, respectively). The median serum Neutrophil/Lymphocyte and TNFα were statistically significantly higher in the SLE starting dialysis patient group than the LN patients and the control group. A cut-off value of ≤ 200 for serum TNFα level and of ≤ 4.8 for Neutrophil/lymphocyte ratio sufficiently differentiated between the LN patients and the SLE patients starting dialysis. TNFα cut-off value showed sensitivity of 76.67%, specificity of 96.67%, positive predictive value of 95.8% and negative predictive value of 80.6 %. Neutrophil/Lymphocyte cut-off showed sensitivity of 70.00%, specificity of 70.00%, positive predictive value of 70.00% and negative predictive value of 70.00 %. Conclusion:  NLR and TNFα serum levels appear to be useful biomarkers for disease flares and tissue injury in LN patients. Both can identify   disease activities, relapses and remissions in lupus nephritis patients.

DOI

10.21608/ejmm.2023.281033

Keywords

Lupus erythematosus, SLE, disease activity, Flares, autoimmune disorder, biomarkers, Nephritis, relapse, Remission, TNF and NLR

Authors

First Name

Shaimaa

Last Name

Fouad

MiddleName

Hani

Affiliation

Department of Internal Medicine /Allergy and Clinical Immunology, Faculty boy Medicine, Ain-Shams University, Cairo, Egypt.

Email

shaimaahani@med.asu.edu.eg

City

-

Orcid

-

First Name

Mohamed

Last Name

Farris

MiddleName

Nazmy

Affiliation

Internal medicine/ Allergy and Clinical Immunology department, Faculty of Medicine, Ain-Shams University, Cairo, Egypt

Email

mnfarris@yahoo.co.uk

City

-

Orcid

-

First Name

Eman

Last Name

Mansour

MiddleName

s

Affiliation

Department of Internal Medicine, Ministry of Health, Cairo, Egypt

Email

emansmansour@gmail.com

City

-

Orcid

-

First Name

Mayada

Last Name

Moneer

MiddleName

-

Affiliation

Internal medicine/ Allergy and Clinical Immunology department, Faculty of Medicine, Ain-Shams University, Cairo, Egypt

Email

madymoneer@gmail.com

City

-

Orcid

-

Volume

32

Article Issue

2

Related Issue

38873

Issue Date

2023-04-01

Receive Date

2023-01-19

Publish Date

2023-04-01

Page Start

49

Page End

57

Print ISSN

1110-2179

Online ISSN

2537-0979

Article File

EJMM_Volume 32_Issue 2_Pages 49-57.pdf

PDF . 418.1kB

Link

https://ejmm.journals.ekb.eg/article_281033.html

Detail API

https://ejmm.journals.ekb.eg/service?article_code=281033

Order

281,033

Type

New and original researches in the field of Microbiology.

Type Code

2,038

Publication Type

Journal

Publication Title

Egyptian Journal of Medical Microbiology

Publication Link

https://ejmm.journals.ekb.eg/

MainTitle

Can Neutrophil to Lymphocyte Ratio, Platelet to Lymphocyte Ratio and Tumor Necrosis Factor Alpha Predict Lupus Nephritis Flares?

Details

Type

Article

Created At

23 Jan 2023