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280275

IL-23 Receptor Expression on T Helper 17 Cells and its Implication in Multiple Sclerosis Relapse

Article

Last updated: 28 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

Diagnostics

Abstract

Background: Multiple Sclerosis (MS) is considered the prototype of neurodegenerative diseases affecting around 2 million people worldwide. MS was marked primarily as an IL-17-mediated autoimmune disease, the hallmark cytokine of T helper (Th) 17 cells. Th 17 cells are considered as one of MS key effectors through the IL-23/IL-17 axis. Objectives: To investigate IL-23 receptor expression on Th17 cells with assessment of serum IL-17 level and their implication in MS relapse. Methodology: Patients included 22 MS patients in remission, 22 MS patients in active relapse and 22 healthy controls. Clinical assessment of the expanded disability severity scale (EDSS) for included patients. All groups were subjected to flow-cytometric analysis to assess expression of IL-23 receptor (IL-23R) on CD4+ T cells and measurement of serum IL-17A level by using ELISA. Results: MS patients during active relapse had a higher IL-17A serum level, and a higher percentage of IL-23R+ CD4+ T cells with increased IL-23R expression density on CD4+ T cells compared to patients in remission and controls. Conclusion:  The results reflected Th 17 key role in MS immune pathogenesis. Thus, the IL-23/IL-17 axis can be a potential target for immunomodulatory therapies ameliorating the Th17 mediated autoimmunity through novel treatments for those patients.

DOI

10.21608/ejmm.2023.280275

Keywords

Neurodegenerative, Cytokines, IL-23, autoreactive, demyelinating

Authors

First Name

Reham

Last Name

Khalifa

MiddleName

Ali

Affiliation

Medical Microbiology and Immunology, Faculty of Medicine, Ain Shams University

Email

drreham_khalifa@med.asu.edu.eg

City

-

Orcid

0000-0003-3012-1164

First Name

Nesma

Last Name

Abdel Aziz

MiddleName

-

Affiliation

Medical Microbiology and Immunology department, Faculty of Medicine, Ain Shams University.

Email

nesma@med.asu.edu.eg

City

Cairo

Orcid

-

First Name

Ali

Last Name

Shalash

MiddleName

-

Affiliation

Neurology department, Faculty of Medicine, Ain Shams University.

Email

ali_neuro@yahoo.com

City

Cairo

Orcid

-

First Name

Maha

Last Name

Nada

MiddleName

-

Affiliation

Neurology department, Faculty of Medicine, Ain Shams University.

Email

drmahanada@yahoo.com

City

Cairo

Orcid

-

First Name

Shimaa

Last Name

Abdel Salam

MiddleName

Ahmed

Affiliation

Medical Microbiology and Immunology department, Faculty of Medicine Ain Shams university

Email

shimaa_ahmed@med.asu.edu.eg

City

Cairo

Orcid

0000-0002-9825-5233

Volume

32

Article Issue

2

Related Issue

38873

Issue Date

2023-04-01

Receive Date

2023-01-14

Publish Date

2023-04-01

Page Start

41

Page End

47

Print ISSN

1110-2179

Online ISSN

2537-0979

Article File

EJMM_Volume 32_Issue 2_Pages 41-47.pdf

PDF . 465.6kB

Link

https://ejmm.journals.ekb.eg/article_280275.html

Detail API

https://ejmm.journals.ekb.eg/service?article_code=280275

Order

280,275

Type

New and original researches in the field of Microbiology.

Type Code

2,038

Publication Type

Journal

Publication Title

Egyptian Journal of Medical Microbiology

Publication Link

https://ejmm.journals.ekb.eg/

MainTitle

IL-23 Receptor Expression on T Helper 17 Cells and its Implication in Multiple Sclerosis Relapse

Details

Type

Article

Created At

23 Jan 2023