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279742

Alarming Antibiotic Resistance Pattern of Bacterial Isolates in Neonatal Sepsis: A Study from Egypt

Article

Last updated: 28 Dec 2024

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Subjects

-

Tags

Clinical microbiology

Abstract

Background: Sepsis in the neonatal intensive care unit (NICU) remains one of the most significant causes of morbidity and mortality, especially for preterm. Multi-drug-resistant-organisms (MDROs) are emerging as important pathogens that cause neonatal sepsis in NICU.  Objective: to review the epidemiology of the microorganisms implicated in neonatal sepsis while shedding the light on the percentage of Multiple-drug-resistant (MDR) and Extensive-Drug-Resistance (XDR) microorganisms in addition to investigating their antibiotic susceptibility pattern. Methodology: This is a cross-sectional prospective study of a 24-month duration including data from culture-proven neonatal sepsis patients admitted at NICU, from Fayoum University Pediatric Hospital. Results: Klebsiella species was the most isolated organism from blood (46%), and 87.6% of isolates were MDR organisms (332/379). The resistance pattern was as follows: 66.5% of resistance owed to Gram-negative bacilli; of them 52% were XDR, 13.2% were MDR, 0.8% were Pan drug Resistant and 0.5% were Difficult-to-Treat (DTR)-Pseudomonas species. Gram-positive cocci were responsible for 21.1 % of MDR; 20.8% MRSA and 0.3% VRE. Total MDR accounted for 34.3% of isolates. The isolates showed significant resistance to most tested antibiotics (p<0.05) (doxycycline, tetracycline, amikacin, cefoxitin, meropenem, imipenem, ertapenem, piperacillin-tazobactam, and ampicillin-sulbactam. Significant sensitivity was detected to linezolid, vancomycin, and tigecycline. Conclusion: There is an alarming increase in the resistance rates among cases of neonatal sepsis. The application of an antibiotic stewardship program is essentially needed to stop the dramatic increase in antibiotic resistance and fight the development of MDROs.

DOI

10.21608/ejmm.2023.279742

Keywords

Neonatal sepsis, Multi-drug-resistant-organisms, Neonatal Intensive Care Unit, Klebsiella species

Authors

First Name

Reham

Last Name

Raafat Hamed

MiddleName

M.

Affiliation

Medical Microbiology and Immunology Department, Faculty of Medicine, Cairo University, Egypt

Email

rehamraafat1986@yahoo.com

City

Giza

Orcid

0000-0002-5526-2134

First Name

Reham

Last Name

Dwedar

MiddleName

-

Affiliation

Medical Microbiology and Immunology Department, Faculty of Medicine, Cairo University, Egypt

Email

rehamdwedar@kasralainy.edu.eg

City

-

Orcid

-

First Name

Rasha

Last Name

Bassyouni

MiddleName

-

Affiliation

Medical Microbiology and Immunology Department, Faculty of Medicine, Fayoum University, Egypt

Email

rhb00@fayoum.edu.eg

City

Giza

Orcid

0000-0003-2468-4948

First Name

Ahmed

Last Name

Emira

MiddleName

S.

Affiliation

MD Medical Microbiology and Immunology, Faculty of Medicine, Cairo University, Egypt; Microbiology Department, Alfa Laboratories, Cairo, Egypt

Email

ahmed_emira@hotmail.com

City

-

Orcid

-

First Name

Rehab

Last Name

Abd El-Hmid

MiddleName

G.

Affiliation

Pediatric Department, Faculty of Medicine, Fayoum University, Egypt

Email

rga01@fayoum.edu.eg

City

-

Orcid

-

First Name

Mona

Last Name

Dowidar

MiddleName

A.

Affiliation

Medical Pharmacology, Faculty of Medicine, Cairo University, Egypt

Email

monadowidar2006@yahoo.com

City

-

Orcid

-

First Name

Asmaa

Last Name

Hegab

MiddleName

-

Affiliation

Medical Microbiology and Immunology Department, Faculty of Medicine, Cairo University, Egypt

Email

asmahgab@kasralainy.edu.eg

City

-

Orcid

0000-0002-6304-652x

Volume

32

Article Issue

2

Related Issue

38873

Issue Date

2023-04-01

Receive Date

2023-01-11

Publish Date

2023-04-01

Page Start

31

Page End

39

Print ISSN

1110-2179

Online ISSN

2537-0979

Article File

EJMM_Volume 32_Issue 2_Pages 31-39.pdf

PDF . 369.9kB

Link

https://ejmm.journals.ekb.eg/article_279742.html

Detail API

https://ejmm.journals.ekb.eg/service?article_code=279742

Order

279,742

Type

New and original researches in the field of Microbiology.

Type Code

2,038

Publication Type

Journal

Publication Title

Egyptian Journal of Medical Microbiology

Publication Link

https://ejmm.journals.ekb.eg/

MainTitle

Alarming Antibiotic Resistance Pattern of Bacterial Isolates in Neonatal Sepsis: A Study from Egypt

Details

Type

Article

Created At

23 Jan 2023