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279738

Role of MICA rs2596542 and IFN-gamma rs2069727 Polymorphism in HCC Development in Egyptian Patients with HCV-related HCC

Article

Last updated: 05 Jan 2025

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Tags

Clinical microbiology

Abstract

Background: Chronic infection with hepatitis C virus (HCV) is considered as a predisposing factor for liver cirrhosis (LC) and hepatocellular carcinoma (HCC). In several malignancies, MICA and IFN-γ genes were found to be highly expressed. Objectives: to identify the impacts of MICA rs2596542 and IFN-γ rs2069727 polymorphisms on LC and HCC development among Egyptian HCV patients, as well as impacts of gene-gene interaction on the disease incidence. Methodology: Blood samples were taken from 75 subjects with confirmed chronic hepatitis C (CHC), HCV-related LC or HCC on top of HCV infection and 25 healthy controls. Genotyping of MICA rs2596542 and IFN-γ rs2069727 polymorphisms were studied using real time PCR and PCR-Restriction fragment length polymorphism (RFLP) respectively. Results: A significantly elevated MICA rs2596542 TT genotype and T allele was found in HCC group (28%) and LC group (28%) compared to control group (16%). CC genotype and C allele were found to be more prevalent in healthy controls (64%) than HCC group (16%) and LC group (24%). AA genotype of IFN-γ rs2069727 SNP and A allele were significantly elevated in control group, while GG genotype and G allele were significantly elevated in HCC and LC groups. In assessing the hazard of HCC development, wild forms of both genes were higher in controls, and this is the protective forms while the mutant forms were elevated in HCC group. Conclusion: MICA rs2596542 and IFN-γ rs2069727 SNPs had significantly implicated in LC and HCC susceptibility.

DOI

10.21608/ejmm.2023.279738

Keywords

HCV, HCC, MICA gene polymorphism, IFN- γ gene polymorphism

Authors

First Name

Asmaa

Last Name

Morsy

MiddleName

Tawfik

Affiliation

Shebin Elkom National liver institute

Email

ahmedelsayedm.tv@gmail.com

City

-

Orcid

-

Volume

32

Article Issue

2

Related Issue

38873

Issue Date

2023-04-01

Receive Date

2023-01-11

Publish Date

2023-04-01

Page Start

9

Page End

16

Print ISSN

1110-2179

Online ISSN

2537-0979

Article File

EJMM_Volume 32_Issue 2_Pages 9-16.pdf

PDF . 561.8kB

Link

https://ejmm.journals.ekb.eg/article_279738.html

Detail API

https://ejmm.journals.ekb.eg/service?article_code=279738

Order

279,738

Type

New and original researches in the field of Microbiology.

Type Code

2,038

Publication Type

Journal

Publication Title

Egyptian Journal of Medical Microbiology

Publication Link

https://ejmm.journals.ekb.eg/

MainTitle

Role of MICA rs2596542 and IFN-gamma rs2069727 Polymorphism in HCC Development in Egyptian Patients with HCV-related HCC

Details

Type

Article

Created At

23 Jan 2023