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277801

Circulating IL 6 and IL 23 Levels in Systemic Lupus Erythematosus Patients and Association with Disease Activity

Article

Last updated: 05 Jan 2025

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Subjects

-

Tags

Clinical microbiology

Abstract

Background: SLE is a systemic autoimmune disease that is characterized by immune mediated tissue damage. Objectives: to determine the serum levels of IL- 6 and IL-23 in SLE patients and to evaluate their association with disease parameters and activity. Methodology: The study included sixty participants that were divided into (30) SLE patients and (30) healthy controls (HCs). Lupus Erythematosus Disease Activity Index (SLEDAI-2K) was assessed. Serum IL-6 and IL-23 level were measured by ELISA in all participants. Results: The SLE patients were 28 females and 2 males with a mean age of 34±11 years. Thirty healthy controls were 27 females and 3 males with a mean age of 40±7 years. The mean disease duration was 6.31± 5.36 with the mean SLEDI-2K 9±7.24 patients had active disease, 73.3% had mucocutaneous manifestations as malar rash, alopecia and oral ulcers, 70% had arthritis, 10% had neuropsychiatric lupus and 17 cases had lupus nephritis confirmed by renal biopsy. IL-6 and IL-23 serum levels were significantly increased in SLE patients than the control group (p < 0.001). Serum IL-6 and IL-23 significantly discriminated SLE patients from healthy controls at a cut-off value of 112.5ng/L and 121.82 ng/L respectively with 83.3% and 96.7% sensitivity and 80% and 90% specificity respectively .Conclusion: Serum levels of IL-6 and IL-23 were elevated in SLE patients in comparison to control group and might be potential biomarkers for disease activity monitoring in SLE patients.

DOI

10.21608/ejmm.2023.277801

Keywords

Interleukin-6, Interleukin-23, SLE

Authors

First Name

Fatma el zahraa

Last Name

Fathy

MiddleName

Y.

Affiliation

Medical Microbiology and Immunology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt

Email

drfatmayoussef@med.asu.edu.eg

City

Cairo

Orcid

0000000267877734

First Name

Rasha

Last Name

Thabet

MiddleName

N.

Affiliation

Internal Medicine and Rheumatology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt

Email

-

City

Cairo

Orcid

-

First Name

Aya

Last Name

Elgendy

MiddleName

-

Affiliation

Internal Medicine and Allergy and Clinical Immunology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt

Email

-

City

Cairo

Orcid

-

First Name

Nagwa

Last Name

abo el magd

MiddleName

Mahmoud

Affiliation

Medical Microbiology and Immunology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt

Email

nagwamahmoud1983@gmail.com

City

-

Orcid

0000-0003-0705-8240

Volume

32

Article Issue

1

Related Issue

38243

Issue Date

2023-01-01

Receive Date

2023-01-01

Publish Date

2023-01-01

Page Start

169

Page End

178

Print ISSN

1110-2179

Online ISSN

2537-0979

Article File

EJMM_Volume 32_Issue 1_Pages 169-178.pdf

PDF . 618.1kB

Link

https://ejmm.journals.ekb.eg/article_277801.html

Detail API

https://ejmm.journals.ekb.eg/service?article_code=277801

Order

277,801

Type

New and original researches in the field of Microbiology.

Type Code

2,038

Publication Type

Journal

Publication Title

Egyptian Journal of Medical Microbiology

Publication Link

https://ejmm.journals.ekb.eg/

MainTitle

Circulating IL 6 and IL 23 Levels in Systemic Lupus Erythematosus Patients and Association with Disease Activity

Details

Type

Article

Created At

23 Jan 2023