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277800

Hyphal wall protein 1 gene and Biofilm formation among Candida albicans isolates from Ain Shams University Hospitals

Article

Last updated: 28 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

Pathogenicity and virulence

Abstract

Background: Candida albicans (C. albicans) is considered a common fungal pathogen, many genes like HWP1 regulates formation of biofilm which is considered as an important mediator of pathogenicity of this organism. Objective: to assess the ability of C. albicans to form biofilm and to determine the association of hyphal wall protein 1 (HWP1) gene and biofilm forming ability of isolates. Methodology: This study was conducted on 30 C. albicans isolates. Detection of biofilm formation was performed by using tissue culture plate method then polymerase chain reaction was done to detect HWP1 gene. Results: Biofilm forming isolates were 14 (46.7%) among tested isolates while HWP1 gene was found in 13 isolates (43.3%). Regarding antifungal susceptibility all isolates were susceptible to Fluconazole, voriconazole, micafungin, and flucytosine, while 93.3% of isolates were found susceptible to amphotericin-B and caspofungin. Conclusion: The rate of biofilm formation among C. albicans is high and is highly associated to presence of HWP1 gene.

DOI

10.21608/ejmm.2023.277800

Keywords

Candida albicans, HWP1 gene, Antifungal susceptibility, biofilm formation

Authors

First Name

Fatma el zahraa

Last Name

Fathy

MiddleName

Youssef

Affiliation

Medical Microbiology and Immunology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt

Email

drfatmayoussef@med.asu.edu.eg

City

CAIRO

Orcid

0000000267877734

First Name

Yasmin

Last Name

Ahmed

MiddleName

Mohamed

Affiliation

Medical Microbiology and Immunology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt

Email

dryasmin.mahmoud@med.asu.edu.eg

City

-

Orcid

0000-0002-1062-1738

First Name

Shimaa

Last Name

Abdel Salam

MiddleName

Ahmed

Affiliation

Medical Microbiology and Immunology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt

Email

shimaa_ahmed@med.asu.edu.eh

City

Cairo

Orcid

0000-0002-9825-5233

Volume

32

Article Issue

1

Related Issue

38243

Issue Date

2023-01-01

Receive Date

2023-01-01

Publish Date

2023-01-01

Page Start

163

Page End

168

Print ISSN

1110-2179

Online ISSN

2537-0979

Article File

EJMM_Volume 32_Issue 1_Pages 163-168.pdf

PDF . 265.6kB

Link

https://ejmm.journals.ekb.eg/article_277800.html

Detail API

https://ejmm.journals.ekb.eg/service?article_code=277800

Order

277,800

Type

New and original researches in the field of Microbiology.

Type Code

2,038

Publication Type

Journal

Publication Title

Egyptian Journal of Medical Microbiology

Publication Link

https://ejmm.journals.ekb.eg/

MainTitle

Hyphal wall protein 1 gene and Biofilm formation among Candida albicans isolates from Ain Shams University Hospitals

Details

Type

Article

Created At

23 Jan 2023