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277796

Unveiling the Risk Factors of Clostridioides difficile Infection in Children; A Multicenter Retrospective Case-control Study in the Eastern Region, Saudi Arabia

Article

Last updated: 28 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

Clinical microbiology

Abstract

Background: Clostridioides difficile (C. difficile) is a major cause of morbidities that ranges in severity from asymptomatic infection to antibiotic associated diarrhea (AAD), and pseudomembranous colitis (PMC). It was recognized that C. difficile infection (CDI) is a disease of advanced age with an increasing incidence worldwide. Notably, children are no longer in the safe zone due to increasing risk of associated comorbidities that predispose to a greater incidence of CDI among this age group. Few data are available to describe the incidence and the risk factors associated with CDI among children in the middle east.  Objective: To identify the risk factors associated with (CDI) in children. Methodology: A multicenter retrospective case-control study was done to review the data collected electronically from the medical records during the five years of the study period. The adjusted and unadjusted regression analysis were used to identify the risk factors. Results: The odd ratio of developing CDI in children is higher than adults (OR:1.52, 95%CI:1.01-2.28, P = 0.0423). Children with asthma (OR:2.77, 95%CI:1.14-6.76, P=0.0251) and children with Sickle cell disease (SCD) (OR: 6.25, 95%CI: 2.03-19.27, P=0.0014) have higher risk of developing CDI. Conclusion: This study demonstrates a higher risk of developing CDI in hospitalized children. A significant association was found between CDI in children and certain comorbidities such as asthma and SCD.

DOI

10.21608/ejmm.2023.277796

Keywords

risk factors, Clostridioides difficile, CDI, children, Asthma, SCD

Authors

First Name

Taghrid

Last Name

Kharboush

MiddleName

Gamaleldin

Affiliation

aDepartment of Medical Microbiology and Immunology, Faculty of Medicine, Benha University, Benha 13518, Egypt; t.g.kharboush@gmail.com b Department of Basic Sciences, College of Sciences and Health Profession, King Saud bin Abdulaziz

Email

t.g.kharboush@gmail.com

City

-

Orcid

-

First Name

Fatima

Last Name

Abu Deeb

MiddleName

-

Affiliation

-Department of Basic Sciences, College of Sciences and Health Profession, King Saud bin Abdulaziz University for Health Sciences, Alahsa 31982, Saudi Arabia -King Abdullah International Medical Research Center, Alahsa 31982, Saudi Arabia

Email

deebf@ksau-hs.edu.sa

City

-

Orcid

-

Volume

32

Article Issue

1

Related Issue

38243

Issue Date

2023-01-01

Receive Date

2023-01-01

Publish Date

2023-01-01

Page Start

157

Page End

162

Print ISSN

1110-2179

Online ISSN

2537-0979

Article File

EJMM_Volume 32_Issue 1_Pages 157-162.pdf

PDF . 273.9kB

Link

https://ejmm.journals.ekb.eg/article_277796.html

Detail API

https://ejmm.journals.ekb.eg/service?article_code=277796

Order

277,796

Type

New and original researches in the field of Microbiology.

Type Code

2,038

Publication Type

Journal

Publication Title

Egyptian Journal of Medical Microbiology

Publication Link

https://ejmm.journals.ekb.eg/

MainTitle

Unveiling the Risk Factors of Clostridioides difficile Infection in Children; A Multicenter Retrospective Case-control Study in the Eastern Region, Saudi Arabia

Details

Type

Article

Created At

23 Jan 2023