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277788

The Prevalence of Panton-Valentine Leukocidin (PVL) gene among Staphylococcus aureus Strains Isolated from Both Medical staff and Community People in Minia Governorate, Egypt

Article

Last updated: 05 Jan 2025

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Subjects

-

Tags

Antimicrobial agents

Abstract

Background: Staphylococcus aureus (S. aureus) is a major virulent human pathogen that is currently the most common cause of infections in hospitalized patients and community people. One of the key virulence factors of S. aureus that causes necrosis, apoptosis, and destruction of leucocytes is known as the Panton-Valentine Leukocidin (PVL) gene. Objective: was to study the distribution of PVL gene among the isolated S. aureus strains from nasal specimens of both medical and community people and compare their resistance profiles. Methodology: in our study, 233 nasal specimens were collected from both the medical staff of Minia University Hospital and the community people. S. aureus was identified by microscopical examination and conventional culture media. The antibiotic sensitivity test was done using a disc diffusion assay. Screening of PVL genes was done using the polymerase chain reaction (PCR). Results: Forty-six (48.4%) and 49 (51.6%) S. aureus isolates from medical staff and the community people were detected respectively. Among 29 PVL-positive S. aureus isolates, there were 8 (17.4%) isolates from medical staff and 21 (42.9%) isolates from community people. It was found that antibiotic resistance percentage among all PVL-negative S. aureus isolates was higher when compared to PVL- positive isolates. Conclusion: This study detected a statistically significant higher percentage of PVL-positive strains among community-isolated S. aureus than medical staff isolates. Therefore broader surveillance of PVL spread is recommended.

DOI

10.21608/ejmm.2023.277788

Keywords

Staphylococcus infection, PCR, The Panton-Valentine leukocidin PVL gene, community-acquired

Authors

First Name

Sahar

Last Name

Mandour

MiddleName

A.

Affiliation

Department of Microbiology and Immunology, Faculty of Pharmacy, Deraya University, Minia, Egypt

Email

sahar.mandour@deraya.edu.eg

City

Minia

Orcid

0000-0003-2500-0480

First Name

Gamal

Last Name

Fadl

MiddleName

A.

Affiliation

Department of Microbiology and Immunology, Faculty of Pharmacy, Minia University, Minia, Egypt

Email

drgamalfadl2014@yahoo.com

City

Minia

Orcid

-

First Name

Salah

Last Name

Abdalla

MiddleName

M.

Affiliation

Department of Microbiology and Immunology, Faculty of Pharmacy Suez Canal University, Ismailia, Egypt

Email

salah1979@hotmail.com

City

Ismailia

Orcid

-

First Name

Fatma

Last Name

Mohamed

MiddleName

Y.

Affiliation

Department of Microbiology and Immunology, Faculty of Pharmacy, Deraya University, Minia, Egypt

Email

fatma.yousry@deraya.edu.eg

City

Minia

Orcid

-

First Name

Heba

Last Name

Mohamed

MiddleName

A.

Affiliation

Department of Microbiology and Immunology, Faculty of Pharmacy, Minia University, Minia, Egypt

Email

ham_phar@yahoo.com

City

Minia

Orcid

-

Volume

32

Article Issue

1

Related Issue

38243

Issue Date

2023-01-01

Receive Date

2023-01-01

Publish Date

2023-01-01

Page Start

125

Page End

132

Print ISSN

1110-2179

Online ISSN

2537-0979

Article File

EJMM_Volume 32_Issue 1_Pages 125-132.pdf

PDF . 626.9kB

Link

https://ejmm.journals.ekb.eg/article_277788.html

Detail API

https://ejmm.journals.ekb.eg/service?article_code=277788

Order

277,788

Type

New and original researches in the field of Microbiology.

Type Code

2,038

Publication Type

Journal

Publication Title

Egyptian Journal of Medical Microbiology

Publication Link

https://ejmm.journals.ekb.eg/

MainTitle

The Prevalence of Panton-Valentine Leukocidin (PVL) gene among Staphylococcus aureus Strains Isolated from Both Medical staff and Community People in Minia Governorate, Egypt

Details

Type

Article

Created At

23 Jan 2023