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277785

Hospital-Acquired Infection by Carbapenem-Resistant Acinetobacter Species in ICUs in Assiut, Egypt

Article

Last updated: 23 Jan 2023

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Subjects

-

Tags

prevention of hospital infections

Abstract

Background: The genus Acinetobacter is one of the main fears of hospital-acquired infection (HAI) wide-reaching mostly in ICUs. Objectives: This study aimed to identify the incidence of carbapenem-resistant Acinetobacter (CRA) HAI in Assiut University Hospitals ICU and determine their antimicrobial susceptibility profile. Methodology: The study included 1204 clinical samples from 928 patients with HAI and 625 environmental samples. Carbapenemase production was detected phenotypically by MIC determination using imipenem, meropenem and doripenem E-test, modified Hodge test, combined disc test and double disc synergy test (DDST). OXA genes (blaOXA-51, blaOXA-23, blaOXA-24, and blaOXA-58) and MβL genes (blaSIM-1, blaVIM, and blaIMP-1) were investigated genotypically by PCR. Results: Out of total 60 Acinetobacter isolates, 55 (91.7%) were extensively drug-resistant (XDR) and 5 (8.3%) were multi-drug resistant (MDR). 93.3% of Acinetobacter isolates were resistant to imipenem and meropenem, and 90% were resistant to doripenem. The prevalence of bla genes in isolates were blaOXA-51 (93.3%), blaOXA-23 (68.3%), blaOXA-24 (23.3%), blaOXA-58 (10%), blaSIM-1 (46.7%), and blaVIM (8.3%). blaIMP-1 was not detected in any isolate. Conclusion: CRA infections were considerable in our ICUs. The high prevalence of XDR Acinetobacter spp. observed in our study was very alarming and requires critical intervention.

DOI

10.21608/ejmm.2023.277785

Keywords

hospital-acquired infection, Carbapenem-resistance, extensive drug-resistance, Acinetobacter

Authors

First Name

Maggie

Last Name

Ibrahim

MiddleName

Abdallah

Affiliation

Microbiology and Immunology Department, Faculty of Medicine, Assiut University

Email

maggie.abdallah@hotmail.com

City

-

Orcid

-

First Name

Shereen

Last Name

Abdallah

MiddleName

-

Affiliation

Microbiology and Immunology Department, Faculty of Pharmacy, Assiut University

Email

shereenahmed1285@gmail.com

City

Assiut

Orcid

-

First Name

Ismail

Last Name

Soliman

MiddleName

Seddik

Affiliation

Microbiology and Immunology department, Assiut university

Email

ismailsoliman37@yahoo.com

City

Assiut

Orcid

-

First Name

Noha

Last Name

Afifi

MiddleName

-

Affiliation

Microbiology and Immunology Department, Faculty of Medicine, Assiut University

Email

nohaafifi2015@aun.edu.eg

City

Assiut

Orcid

-

First Name

Michael

Last Name

Atiat Allah

MiddleName

Nazmy Agban

Affiliation

Medical Microbiology and Immunology , Faculty of Medicine, Assiut University,

Email

agbanmichael@yahoo.com

City

Asyut

Orcid

-

Volume

32

Article Issue

1

Related Issue

38243

Issue Date

2023-01-01

Receive Date

2023-01-01

Publish Date

2023-01-01

Page Start

97

Page End

104

Print ISSN

1110-2179

Online ISSN

2537-0979

Article File

EJMM_Volume 32_Issue 1_Pages 97-104.pdf

PDF . 451.5kB

Link

https://ejmm.journals.ekb.eg/article_277785.html

Detail API

https://ejmm.journals.ekb.eg/service?article_code=277785

Order

277,785

Type

New and original researches in the field of Microbiology.

Type Code

2,038

Publication Type

Journal

Publication Title

Egyptian Journal of Medical Microbiology

Publication Link

https://ejmm.journals.ekb.eg/

MainTitle

-

Details

Type

Article

Created At

23 Jan 2023