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277765

T-cell Expression of CD 4, 8, and 137 among Naïve Patients with Major Depressive Disorder: A Comparative Study

Article

Last updated: 05 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

Epidemiology

Abstract

Background: Major depressive disorder (MDD) is one of the most prevalent psychiatric and immune system illnesses worldwide. Recent studies have found a possible relationship between MDD and immune dysregulation, which manifests as an alteration in inflammatory biomarkers. Objectives: We aim to investigate the role of CD4, CD8, and CD137 expressions on T cells among patients suffering from major depressive disorder (MDD) not under treatment in comparison with normal individuals. Methodology: The current study was comparative and descriptive conducted on middle-aged patients (age range 18-60 years old) who were diagnosed with MDD. Assessing the differences in T cell expression of CD 4, CD 8, and CD 137 molecules between MDD cases and healthy controls was the primary outcome of our study. Results: In this study, we included 50 patients with MDD and a similar number of healthy controls. In terms of the primary outcomes of the present study. The study results found statistically significant differences between cases and controls in terms of CD4 (P=0.001), CD8 (P=0.001), and CD137 expression (P=0.001). MMD patients had significantly lower expression of CD4 (582.88 ± 133.13 versus 775.04±159.6 in the control group), CD8 (374.24 ±204.8 versus 524.04 ± 195.3 in the control group), and CD137 (391.04 ±158.2 versus 587.52±191.7 in the control group). Conclusion:  We can state that there is a strong association between immune status and patients with MDD, especially naïve patients. This was confirmed according to the significant decrease in the CD4, CD8, and CD137 levels.

DOI

10.21608/ejmm.2023.277765

Keywords

major depressive disorder, CD molecules, CD expression, CD4, CD8, CD137

Authors

First Name

Mahmoud

Last Name

El-Ansary

MiddleName

-

Affiliation

Department of Immunology and Medical Microbiology, Faculty of Medicine, Misr University for Science and Technology, Giza, Egypt

Email

melansary2022@gmail.com

City

-

Orcid

0000-0003-2458-1930

Volume

32

Article Issue

1

Related Issue

38243

Issue Date

2023-01-01

Receive Date

2023-01-01

Publish Date

2023-01-01

Page Start

13

Page End

17

Print ISSN

1110-2179

Online ISSN

2537-0979

Article File

EJMM_Volume 32_Issue 1_Pages 13-17.pdf

PDF . 214.7kB

Link

https://ejmm.journals.ekb.eg/article_277765.html

Detail API

https://ejmm.journals.ekb.eg/service?article_code=277765

Order

277,765

Type

New and original researches in the field of Microbiology.

Type Code

2,038

Publication Type

Journal

Publication Title

Egyptian Journal of Medical Microbiology

Publication Link

https://ejmm.journals.ekb.eg/

MainTitle

T-cell Expression of CD 4, 8, and 137 among Naïve Patients with Major Depressive Disorder: A Comparative Study

Details

Type

Article

Created At

23 Jan 2023