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265442

Evaluation of Soluble CD25 as a Marker in Chronic Liver Diseases in Children

Article

Last updated: 28 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

Diagnostics

Abstract

Background: Based on the crucial pathogenic role of inflammation for the progress of hepatic disorders, we hypothesized that the soluble interleukin-2 receptor (sIL-2R, also known as s CD25) would be a sign of inflammatory cell activation and disease severity in people with chronic liver diseases (CLD). Objectives: Our study aimed to evaluate soluble CD25 as a possible indicator of immune cell activation in CLD and acute liver diseases in a group of pediatric Egyptian patients. Methodology: This study was a case control study that included 120 children presented with liver disease aged 2 month-15 years and 60 unrelated healthy controls. The patients were recruited from Pediatric Hepatology Clinic, Beni- Suef University. All children were subjected to history taking, full clinical examination, laboratory tests (CBC, GGT, ALP, AST, ALT, serum albumin, PT, PC, PTT, INR and Soluble CD25 level). Results: Children with chronic liver disease with fibrosis had serum sIL-2R levels that were considerably lower (19.16±12.33 ng/ml) than children with acute liver disease (27.65±14.19 ng/ml) (p=0.036) and controls (29.23±13.20 ng/ml) (p=0.008). Children with chronic liver disease without fibrosis had a mean CD25 level of (23.33±16.31 ng/ml), which was not statistically different from other groups (p=0.655). Conclusions: further research is needed to clarify the role of sCD25 as an immunological marker to predict the occurrence of liver fibrosis in pediatric hepatic disorders and to differentiate between acute & chronic hepatic disorders.

DOI

10.21608/ejmm.2022.265442

Keywords

Soluble CD25, immunological marker, Chronic liver disease, Liver fibrosis, Interleukin-2 receptor

Authors

First Name

Shaimaa

Last Name

Mohammed

MiddleName

Abdel Tawab

Affiliation

specialist of pediatrics Beni-Suef Specialized Hospital

Email

shaimaa26122010@gmail.com

City

Beni-Suef

Orcid

-

First Name

osamaa

Last Name

Botrous

MiddleName

Ezzat

Affiliation

Professor of Pediatrics Faculty of Medicine , Beni-Suef University

Email

osama.ahmed276@gmail.com

City

-

Orcid

-

First Name

Mahmoud

Last Name

Abd Elkhalek

MiddleName

-

Affiliation

Department of Pediatrics, Faculty of medicine Beni-Suef University

Email

mahmoudhodieb18@gmail.com

City

Beni-Suef

Orcid

-

First Name

Mostafa

Last Name

Abdel-Motaleb

MiddleName

Saleh

Affiliation

Department of Medical Microbiology & Immunology, Faculty of Medicine – Beni-Suef University.

Email

dr.m.sheemy@gmail.com

City

-

Orcid

-

Volume

31

Article Issue

4

Related Issue

36977

Issue Date

2022-10-01

Receive Date

2022-10-14

Publish Date

2022-10-01

Page Start

157

Page End

164

Print ISSN

1110-2179

Online ISSN

2537-0979

Article File

EJMM_Volume 31_Issue 4_Pages 157-164.pdf

PDF . 351.2kB

Link

https://ejmm.journals.ekb.eg/article_265442.html

Detail API

https://ejmm.journals.ekb.eg/service?article_code=265442

Order

265,442

Type

New and original researches in the field of Microbiology.

Type Code

2,038

Publication Type

Journal

Publication Title

Egyptian Journal of Medical Microbiology

Publication Link

https://ejmm.journals.ekb.eg/

MainTitle

Evaluation of Soluble CD25 as a Marker in Chronic Liver Diseases in Children

Details

Type

Article

Created At

23 Jan 2023