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262696

Genetic polymorphism in IL-28 B and LMP-7 genes: Role in HCV-induced Hepatocellular Carcinoma

Article

Last updated: 05 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

Genetics

Abstract

Hepatocellular carcinoma (HCC) is a major health problem that differs epidemiologically across the world. Its pathogenesis is contributed to many factors, and chronic hepatitis viral infections which considered the main risk factor in Egypt. Host genetic factors are considered the most important determinants for the development of HCC especially Single-nucleotide polymorphisms (SNPs). Hepatitis C Virus (HCV) infection is a major health problem with 185 million people infected globally based on the estimation of the World Health Organization (WHO). Persistent infection with HCV can cause liver cirrhosis and/or hepatocellular carcinoma (HCC). HCC is considered the fifth most common type of cancer, killing about 600,000 patients every year. About 30% of HCV- infected patients clear the infection naturally, while the remaining 70% develop chronic disease of which 1 - 2% experience HCC. Determining HCV-infected patients are at risk of developing HCC is crucial whose need continuing surveillance for early detection and treatment of HCC and other liver disease. A number of factors including viral, environmental, and genetic factors, work together to determine the progression of disease in HCV infection.

DOI

10.21608/ejmm.2022.262696

Keywords

HCV, IL 28B, LMP-7, HCC

Authors

First Name

Noha

Last Name

Elmekawy

MiddleName

Saad

Affiliation

Medical Microbiology & Immunology Department, Faculty of Medicine, Mansoura University, Egypt

Email

nohaelmekawy@mans.edu.eg

City

-

Orcid

-

First Name

Sahar

Last Name

Mohamed

MiddleName

T.

Affiliation

Medical Microbiology & Immunology Department, Faculty of Medicine, Mansoura University, Egypt

Email

-

City

Mansoura

Orcid

-

First Name

Sanaa

Last Name

Mohei El-dein

MiddleName

-

Affiliation

Medical Microbiology & Immunology Department, Faculty of Medicine, Mansoura University, Egypt

Email

-

City

Mansoura

Orcid

-

First Name

Mona

Last Name

Arafa

MiddleName

M.

Affiliation

Tropical Medicine Department, Faculty of Medicine, Mansoura University, Egypt

Email

-

City

Mansoura

Orcid

-

First Name

Noha

Last Name

Abou El-Khier

MiddleName

T.

Affiliation

Medical Microbiology & Immunology Department, Faculty of Medicine, Mansoura University, Egypt

Email

-

City

Mansoura

Orcid

-

Volume

31

Article Issue

4

Related Issue

36977

Issue Date

2022-10-01

Receive Date

2022-10-01

Publish Date

2022-10-01

Page Start

107

Page End

111

Print ISSN

1110-2179

Online ISSN

2537-0979

Article File

EJMM_Volume 31_Issue 4_Pages 107-111.pdf

PDF . 376.4kB

Link

https://ejmm.journals.ekb.eg/article_262696.html

Detail API

https://ejmm.journals.ekb.eg/service?article_code=262696

Order

262,696

Type

Review articles

Type Code

2,039

Publication Type

Journal

Publication Title

Egyptian Journal of Medical Microbiology

Publication Link

https://ejmm.journals.ekb.eg/

MainTitle

Genetic polymorphism in IL-28 B and LMP-7 genes: Role in HCV-induced Hepatocellular Carcinoma

Details

Type

Article

Created At

23 Jan 2023