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262693

HLA DRB1 Alleles in Association with Chronic Hepatitis C Virus Infection and Autoimmune Hepatitis

Article

Last updated: 05 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

Genetics

Abstract

Background: Hepatitis C virus is a hepatotropic and lymphotropic virus that has been associated with various diseases and syndromes. Autoimmune hepatitis is a chronic disease of unknown etiology, marked by the continuous inflammation of hepatocytes and necrosis and has a tendency to advance to cirrhosis. Objective: A comparative study between cases of chronic HCV infection and AIH cases regarding different parameters including their genetic association with HLA class II alleles: DRB1*01* - DRB115. Methodology: The study included Eighty subjects, Group I: 30 chronic HCV, Group II: 30 AIH, Group III: 20 healthy controls. HLA Typing was performed using a line probe assay. Results: HLA DRB1∗07, DRB1∗11 were highly associated with HCV clinical cases. DRB1*3 and DRB1*5 were the predominant alleles in AIH (representing 66.7% and 53.3% respectively). Conclusion: Certain HLA alleles of class II could be linked to hepatitis cases (either caused by HCV or autoimmune) and can predict clinical course and outcome of the disease.

DOI

10.21608/ejmm.2022.262693

Keywords

HCV, Autoimmune hepatitis, HLA typing, HLA DRB, Autoantibodies

Authors

First Name

Amira

Last Name

Shalaa

MiddleName

-

Affiliation

Medical Microbiology and Immunology Faculty of Medicine Alexandria University

Email

amira.shalaa@alexmed.edu.eg

City

-

Orcid

-

First Name

Mona

Last Name

Morsi

MiddleName

-

Affiliation

Medical Microbiology and Immunology Department, Faculty of Medicine, University of Alexandria, Egypt

Email

morsirg@gmail.com

City

Alexandria

Orcid

-

First Name

Mohamed

Last Name

Ahmed

MiddleName

Abd elrahman

Affiliation

Clinical Pathology, Armed Forces Medical Academy, Alexandria, Egypt

Email

mohamed_rhman1963@yahoo.com

City

-

Orcid

-

First Name

Khalid

Last Name

Al Zaafarany

MiddleName

-

Affiliation

Faculty of Medicine Alexandria University

Email

khaliffessal@gmail.com

City

-

Orcid

-

First Name

Shams

Last Name

Arafa

MiddleName

Abd elfattah

Affiliation

Medical microbiology and immunology, faculty of medicine, Alexandria university

Email

shams.arafa@alexmed.edu.eg

City

Alexandria

Orcid

0000-0002-9683-4530

Volume

31

Article Issue

4

Related Issue

36977

Issue Date

2022-10-01

Receive Date

2022-10-01

Publish Date

2022-10-01

Page Start

93

Page End

101

Print ISSN

1110-2179

Online ISSN

2537-0979

Article File

EJMM_Volume 31_Issue 4_Pages 93-101.pdf

PDF . 366.0kB

Link

https://ejmm.journals.ekb.eg/article_262693.html

Detail API

https://ejmm.journals.ekb.eg/service?article_code=262693

Order

262,693

Type

New and original researches in the field of Microbiology.

Type Code

2,038

Publication Type

Journal

Publication Title

Egyptian Journal of Medical Microbiology

Publication Link

https://ejmm.journals.ekb.eg/

MainTitle

HLA DRB1 Alleles in Association with Chronic Hepatitis C Virus Infection and Autoimmune Hepatitis

Details

Type

Article

Created At

23 Jan 2023