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Cytomegalovirus and Epstein–Barr Virus Infection: Two Triggers flaring up Systemic Lupus Erythematosus Patients

Article

Last updated: 05 Jan 2025

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Tags

Clinical microbiology

Abstract

Background: Systemic lupus erythematosus (SLE) is an autoimmune, multi-system, chronic inflammatory disease The effect of Cytomegalovirus(CMV) and Epstein-Barr virus(EBV) in triggering SLE has been investigated for many years. Objectives: To study the association of viral load of CMV-EBV in the serum of SLE patients' with SLE disease parameters. Methodology: 48SLE patients and 40controls were enrolled. Disease activity was assessed using SLE disease activity index (SLEDAI). Quantitation of CMV and EBV-DNA in serum were detected by real-time polymerase chain reaction. Results: Patients were 91.8% females and 8.2%males. Mean age was 26.6±8.0 years, mean disease duration 4.5±3.1 years, and age at onset 22.1±7.8 years. 41.7% of SLE patients had CMV-DNA, 54.2% patients had EBV-DNA. Neither EBV-DNA nor CMV-DNA were found in the healthy controls. Copy numbers of CMV and EBV found in the serum of SLE patients were 26827±25879copies/μl, and 25309±22852copies/μl, respectively. Regarding SLEDAI; 83.3% showed high disease activity. Renal biopsy revealed that, 66.7% of the patients had lupus nephritis; 50% with CMV-DNA, and 56.25% with EBV-DNA. Regarding the association between CMV and EBV with different disease parameters in SLE patients; we found significant associations with: photosensitivity, Raynaud's and thrombocytopenia (pvalue<0.05). EBV-DNA were significantly associated with: pyuria, oral ulcers, photosensitivity, vasculitis and involvement of nervous system (r=0.43, p=0.002), (r=0.36, p=0.01), (r=0.42, p=0.003), (r=-0.33, p=0.023), (r=0.32, p=0.029) respectively. Conclusions: A high incidence of CMV and EBV was detected in SLE patients with increased viral load. Disease activity of SLE patients is significantly higher in patients infected with CMV and EBV compared to non-infected.

DOI

10.21608/ejmm.2022.262692

Keywords

Systemic lupus erythematosus, Cytomegalovirus, Epstein-Barr virus SLEDA

Authors

First Name

reham

Last Name

raafat hamed

MiddleName

mohammad

Affiliation

Medical Microbiology and Immunology Department, Faculty of Medicine, Cairo University, Egypt

Email

rehamraafat1986@yahoo.com

City

giza

Orcid

0000-0002-5526-2134

First Name

Rasha

Last Name

Bassyouni

MiddleName

-

Affiliation

Fayoum Faculty of Medicine

Email

rhb00@fayoum.edu.eg

City

Giza

Orcid

0000-0003-2468-4948

First Name

hanan

Last Name

fathi

MiddleName

-

Affiliation

Rheumatology and Rehabilitation Department, Faculty of Medicine, Fayoum University, Egypt

Email

h.fathi@yahoo.com

City

Cairo

Orcid

0000-0003-1964-305X

First Name

amul

Last Name

badr

MiddleName

m

Affiliation

Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Cairo University, Egypt

Email

amal.abdelrehem@kasralainy.edu.eg

City

-

Orcid

-

First Name

marwa

Last Name

amer

MiddleName

f

Affiliation

Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Cairo University, Egypt

Email

marwa.fathy@kasralainy.edu.eg

City

-

Orcid

-

First Name

reham

Last Name

dwedar

MiddleName

-

Affiliation

Medical Microbiology and Immunology Department, Faculty of Medicine, Cairo University, Egypt

Email

rehamdwedar@kasralainy.edu.eg

City

-

Orcid

-

Volume

31

Article Issue

4

Related Issue

36977

Issue Date

2022-10-01

Receive Date

2022-10-01

Publish Date

2022-10-01

Page Start

83

Page End

91

Print ISSN

1110-2179

Online ISSN

2537-0979

Article File

EJMM_Volume 31_Issue 4_Pages 83-91.pdf

PDF . 363.6kB

Link

https://ejmm.journals.ekb.eg/article_262692.html

Detail API

https://ejmm.journals.ekb.eg/service?article_code=262692

Order

262,692

Type

New and original researches in the field of Microbiology.

Type Code

2,038

Publication Type

Journal

Publication Title

Egyptian Journal of Medical Microbiology

Publication Link

https://ejmm.journals.ekb.eg/

MainTitle

Cytomegalovirus and Epstein–Barr Virus Infection: Two Triggers flaring up Systemic Lupus Erythematosus Patients

Details

Type

Article

Created At

23 Jan 2023