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262665

Clinical significance of viral loads in patients infected with SARS-CoV-2 in Fayoum University Hospitals

Article

Last updated: 05 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

virology

Abstract

Background: Throughout unexplained cases of pneumonia, a new human coronavirus first found in Wuhan, China in December 2019 had spread worldwide. Viral loads from respiratory samples were measured and considered an indication of active virus replication and used for monitoring severe viral respiratory tract infections routinely. Objective: is to evaluate if the nasopharyngeal viral load has any link with known clinical parameters at disease progression in cases infected with (SARS-CoV-2) during the early three months (May, June, July /2020) of the epidemic in Fayoum University Hospitals. Methodology: Nasopharyngeal swabs were taken from cases with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and viral loads were detected by real-time Reversed transcriptase polymerase chain reaction (RT-PCR) according to cycle threshold (Ct) where high viral load means Ct value <25, moderate viral load; Ct value is from 25 to 35 and low viral load means Ct value >35. Results: Moderate and high NP viral load were significantly higher in patients with fever, upper respiratory tract symptoms, bone aches, and vomiting. High levels of both CRP (p=0.021) and CT findings (p=0.005) were significantly associated with moderate and high viral load. There were significant differences between viral loads groups as regards the occupation of HCWs (p=0.005). Conclusion: SARS-CoV-2 viral load were high in the nasopharynx at the early phase of infection; also high viral load were noticed more in HCWs.

DOI

10.21608/ejmm.2022.262665

Keywords

Viral loads, COVID-19, SARS-CoV-2

Authors

First Name

Hossam-Eldin

Last Name

Ali

MiddleName

Mahmoud

Affiliation

Clinical and chemical pathology department, Faculty of Medicine, Fayoum University, Fayoum, Egypt.

Email

hma05@fayoum.edu.eg

City

-

Orcid

0000-0002-8748-3126

First Name

Radwa

Last Name

Elhefny

MiddleName

A

Affiliation

Department of Chest Diseases, Faculty of Medicine, Fayoum University, Egypt.

Email

rah02@fayoum.edu.eg

City

Fayoum

Orcid

-

First Name

Noha

Last Name

Abdel-Ghafaar

MiddleName

Khalifa

Affiliation

Department of Clinical and chemical pathology, Faculty of Medicine, Fayoum University, Egypt

Email

khalifa.noha@yahoo.com

City

Fayoum

Orcid

-

First Name

Wafaa

Last Name

Abdel-Wahed

MiddleName

Y

Affiliation

Department of Public health and Community Medicine, Faculty of Medicine, Fayoum University, Egypt

Email

wya00@fayoum.edu.eg

City

Fayoum

Orcid

-

First Name

Fadwa

Last Name

Abdel Reheem

MiddleName

-

Affiliation

Department of Clinical and chemical pathology, Faculty of Medicine, Fayoum University, Egypt.

Email

fadwa_abdelreheem@yahoo.com

City

-

Orcid

-

Volume

31

Article Issue

4

Related Issue

36977

Issue Date

2022-10-01

Receive Date

2022-10-01

Publish Date

2022-10-01

Page Start

1

Page End

4

Print ISSN

1110-2179

Online ISSN

2537-0979

Article File

EJMM_Volume 31_Issue 4_Pages 1-4.pdf

PDF . 286.1kB

Link

https://ejmm.journals.ekb.eg/article_262665.html

Detail API

https://ejmm.journals.ekb.eg/service?article_code=262665

Order

262,665

Type

New and original researches in the field of Microbiology.

Type Code

2,038

Publication Type

Journal

Publication Title

Egyptian Journal of Medical Microbiology

Publication Link

https://ejmm.journals.ekb.eg/

MainTitle

Clinical significance of viral loads in patients infected with SARS-CoV-2 in Fayoum University Hospitals

Details

Type

Article

Created At

23 Jan 2023