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251698

Utility of Alpha-Fetoprotein-L3 and Golgi Protein 73 for Diagnosis of Hepatocellular Carcinoma

Article

Last updated: 23 Jan 2023

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Tags

Diagnostics

Abstract

Background: Hepatocellular carcinoma (HCC) is amongst the most common malignant tumors that carries a poor prognosis. Clinically, alpha-fetoprotein (AFP) is the most extensively used serum biomarker for diagnosing HCC. Objectives: The current study was conducted to explore the diagnostic value of serum levels of alpha-fetoprotein-L3 (AFP-L3) and Golgi protein 73 (GP73) regarding HCC, and to determine the diagnostic accuracy of these biomarkers when used individually as well as in combination with AFP. Methodology: Blood samples were collected from 50 patients with HCV-related cirrhosis (25 subjects with HCC and 25 without HCC) recruited from the outpatient clinics of the Specialized Internal Medicine Hospital, Mansoura University, Egypt. Serum concentrations of AFP-L3 and GP73 were evaluated using enzyme-linked immunosorbent assay (ELISA). Diagnostic performance of AFP-L3 and GP73 was determined by receiver operating characteristic (ROC) curve analysis. Results: Overall, the median serum level of AFP-L3 was higher in the HCC group compared to the cirrhotic group (p=0.05). Moreover, a statistically-significant difference was observed between the median serum value of GP73 in HCC patients compared to those with cirrhosis (p < 0.001). The ROC curve analysis showed that the area under the ROC curve (AUROC) values for AFP, AFP-L3 and GP73 were 0.88, 0.67 and 0.83, respectively. Of the 3 biomarkers, GP73 demonstrated the highest sensitivity (88%). The AUROC for AFP and AFP-L3 combination was 0.85, whereas that for AFP and GP73 was 0.90. Conclusion: Our findings indicate that GP73 is more sensitive than AFP and AFP-L3 in diagnosing HCC. Furthermore, the combined determination of GP73 and AFP could improve the diagnostic ability of HCC.

DOI

DOI:https://doi.org/10.51429/EJMM29402

Keywords

Hepatocellular carcinoma (HCC), Alpha-fetoprotein (AFP), alpha-fetoprotein-L3 (AFP-L3), Golgi protein 73 (GP73), ROC curve

Authors

First Name

Rania

Last Name

El-Kady

MiddleName

A.

Affiliation

Department of Medical Microbiology and Immunology, Faculty of Medicine, Mansoura University, Egypt

Email

-

City

-

Orcid

-

First Name

Mohammed

Last Name

El-Naggar

MiddleName

M.

Affiliation

Department of Medical Microbiology and Immunology, Faculty of Medicine, Mansoura University, Egypt

Email

-

City

-

Orcid

-

First Name

Rehab

Last Name

Abd El-Shakour

MiddleName

A.

Affiliation

Ministry of Health, Egypt

Email

-

City

-

Orcid

-

First Name

Monir

Last Name

Bahgat

MiddleName

H.

Affiliation

Specialized Internal Medicine Hospital, Faculty of Medicine, Mansoura University, Egypt

Email

-

City

-

Orcid

-

Volume

29

Article Issue

4

Related Issue

35876

Issue Date

2020-10-01

Receive Date

2022-07-28

Publish Date

2020-10-01

Page Start

9

Page End

15

Print ISSN

1110-2179

Online ISSN

2537-0979

Article File

EJMM_Volume 29_Issue 4_Pages 9-15.pdf

PDF . 453.5kB

Link

https://ejmm.journals.ekb.eg/article_251698.html

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https://ejmm.journals.ekb.eg/service?article_code=251698

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251,698

Type

New and original researches in the field of Microbiology.

Type Code

2,038

Publication Type

Journal

Publication Title

Egyptian Journal of Medical Microbiology

Publication Link

https://ejmm.journals.ekb.eg/

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Details

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Article

Created At

23 Jan 2023