Background: Since the introduction of the AllergoOncology term that investigates the relationship between allergy and cancer diseases, this relationship has gained intense interest. Additionally individual molecules that play key role in the allergic conditions had gain attention. However, researches had led to conflict results. Objective: The aim of this work is to find out the relation between the allergy and solid cancer. Methodology: This study included 50 cancer patients suffered from solid tumors and 50 healthy controls. Cancer was diagnosed and staged according to the NCCN guidelines. We diagnosed allergic conditions according to the international guidelines. To determine allergen sensitization, we performed skin prick testing (SPT) and measured serum-Specific IgE whenever SPT could not be preformed. Results: The incidence of allergy in control group was significantly higher than that in the patient group groups (P=0.009). Odds ratios between allergy and cancer specific site were insignificant. Conclusion: Allergy may be protective against solid tumors. However, no specific relation between allergy and cancer specific site has been detected.