Background: Essential oils possess antibacterial activity, so they are used to control the antibiotic resistant bacteria isolated from sore throat patients. Objective: This study represents a trial to solve the problem of resistance of some harmful pathogenic bacteria to traditional antibiotics through testing the antibacterial effect of some safe essential oils extracted against the resistant strains. Methodology: The study was conducted on 100 patients with different age and sex who complained with sore throat infection from Outpatients and Inpatients Departments of Otorhinolaryngology and Pediatrics, Benha Teaching Hospital during the period from May 2017 to August 2019. 100 Throat swabs were subjected to culture, isolation and identification of isolated bacteria which were tested for their susceptibilities to antibiotics, essential oils and combinations of both antibiotics and essential oils. The highest effect of essential oils on bacterial cell was detected by scanning and transmission electron microscope. Results: The results showed that essential oils have antibacterial activity against some multidrug resistant bacteria(MDR) and a combination between antibiotics and essential oils is a second chance to face the resistance as they were more effective against different bacterial isolates than using each one of them individually. Conclusion: The essential oils might be exploited as natural antibiotic for the treatment of several infectious diseases overcoming the problem of bacterial resistance to traditional antibiotics.