Background: Currently, getting rid of schistosomiasis, which is classified as tropical ignored parasitic disease and endemic in Egypt, is a national goal. Objectives: Our work was constructed on detection of Schistosoma mansoni (S. mansoni) among school children using multi-stage survey in Menoufia Governorate, Egypt which is known to be endemic for the disease. Methodology; Formol ether concentration technique was applied as a golden test for stool samples and was compared to Kato-katz procedure, IHA, and FDA (Fast dot ELISA for antigen detection) being the available kits currently used in diagnosis. Results: From our survey; we found that schistosomiasis mansoni accounted for 1.5% of the studied population. Infections were higher in Boys than in girls, 2.0% and 1.0 % respectively. S. mansoni infections were associated with anemia in 62% of children. The percent of reinfection of treated children was 0.4%. Infections were significantly higher among children with high rate of contact with canal water. Conclusion: From our survey, we found that schistosomiasis mansoni is still represented in Menoufia Governorate with susceptibly to reinfection after MDT, which rises the alarm to the use of different combined methods for elimination of this endemic disease. We should offer another rapid detection method instead. FDA test was the least sensitive test in diagnosis.