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249537

Relation between Interleukin -4 (590C/T) Gene Polymorphism and Hepatocellular Carcinoma Risk in HBV and HCV Patients

Article

Last updated: 23 Jan 2023

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-

Tags

virology

Abstract

Background: Interleukin-4 (IL-4) is an important modulator in the immune response of macrophages, B and T cells to stand in front of infections and malignancy. Objectives: This study aimed to assess the association between IL-4 gene 590C\T polymorphism and risk of hepatocellular carcinoma (HCC) on top of viral hepatitis. Methodology: This study was conducted on 220 patients and 60 apparently healthy individuals. One hundred and twenty patients with HCV infection (group 1) classified as sixty patients with liver cirrhosis and sixty with HCC, one hundred patients with HBV infection (group 2) classified as fifty with liver cirrhosis and fifty with HCC. Virus status of the patients was confirmed by measuring HBsAg, HCV antibodies and real time PCR. Liver cirrhosis was assessed by laboratory investigations, abdomino-pelvic ultrasound and CHILD score. Patients with HCC were diagnosed by triphasic CT, alphafeto-protein level (AFP) and biopsy. The studied groups were genotyped for IL-4 590C/T gene polymorphisms by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Results: IL-4 590C/T gene analysis detected significant variation between studied groups, regarding genotype and allele frequencies (p=0.025 and p=0.002 respectively). There were higher frequencies of CC genotype and C allele in HCC and cirrhotic hepatitis C patients than controls. C allele had higher prevalence in HCC than cirrhosis in HBV patients. CT+CC genotype carriers had an elevated HCC risk odd ratio (OR): 4.6 [95% CI: 1.5 –14] and OR 3.6 [95% CI: 1.1 –11.6], in HCV and HBV patients in contrast to controls. C allele was associated with increased cirrhotic and HCC risk in HCV infected patients with OR= 4 [95% CI: 1.8 – 8.8] and OR= 2.3 [95% CI: 1.1 – 5.2] versus control group. In HBV patients C allele showed higher HCC risk with OR= 4.2 [95% CI: 1.8 – 9.5] when compared to controls. Conclusion: IL-4 590C/T gene polymorphism may have a role in occurrence of HCC on top of liver cirrhosis.  

DOI

10.21608/ejmm.2020.249537

Keywords

Risk, carcinoma, Hepatocellular carcinoma, interleukin-4, Gene, Polymorphism

Authors

First Name

Naglaa

Last Name

Elabd

MiddleName

S.

Affiliation

Tropical Medicine, Department, Faculty of Medicine, Menoufia University, Egypt

Email

-

City

-

Orcid

-

First Name

Belal

Last Name

Montaser

MiddleName

A.

Affiliation

Clinical Pathology, Department, Faculty of Medicine, Menoufia University, Egypt

Email

-

City

-

Orcid

-

First Name

Mervate

Last Name

Nassar

MiddleName

R.

Affiliation

Tropical Medicine, Department, Faculty of Medicine, Menoufia University, Egypt

Email

-

City

-

Orcid

-

First Name

Eman

Last Name

Salem

MiddleName

H.

Affiliation

Medical Microbiology and Immunology, Faculty of Medicine, Menofia University, Egypt

Email

-

City

-

Orcid

-

First Name

Amany

Last Name

Saleh

MiddleName

A.

Affiliation

Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Menoufia University, Egypt

Email

-

City

-

Orcid

-

First Name

Suzy

Last Name

Gohar

MiddleName

F.

Affiliation

Clinical Oncology department, Faculty of Medicine, Menoufia University, Egypt

Email

-

City

-

Orcid

-

First Name

Ghada

Last Name

Abo-Zeid

MiddleName

S.

Affiliation

Clinical Oncology department, Faculty of Medicine, Menoufia University, Egypt

Email

-

City

-

Orcid

-

First Name

Mahmoud

Last Name

Rizk

MiddleName

-

Affiliation

Internal Medicine department, Faculty of Medicine, Banha University, Egypt

Email

-

City

-

Orcid

-

First Name

Moamena

Last Name

Elhamoly

MiddleName

S.

Affiliation

Tropical Medicine, Department, Faculty of Medicine, Menoufia University, Egypt

Email

-

City

-

Orcid

-

Volume

29

Article Issue

1

Related Issue

35680

Issue Date

2020-01-01

Receive Date

2022-07-18

Publish Date

2020-01-01

Page Start

1

Page End

9

Print ISSN

1110-2179

Online ISSN

2537-0979

Article File

EJMM_Volume 29_Issue 1_Pages 1-9.pdf

PDF . 406.4kB

Link

https://ejmm.journals.ekb.eg/article_249537.html

Detail API

https://ejmm.journals.ekb.eg/service?article_code=249537

Order

249,537

Type

New and original researches in the field of Microbiology.

Type Code

2,038

Publication Type

Journal

Publication Title

Egyptian Journal of Medical Microbiology

Publication Link

https://ejmm.journals.ekb.eg/

MainTitle

-

Details

Type

Article

Created At

23 Jan 2023