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256008

Multidrug-Resistant Gram-Negative ESKAPE Pathogens from a Tertiary-Care Hospital: Prevalence and Risk Factors

Article

Last updated: 05 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

Clinical microbiology

Abstract

Background: Antibiotic-resistant ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species) are commonly implicated in health-care associated infections (HAIs). Objectives: The purpose of this study is to assess the antimicrobial susceptibility profile of Gram-negative ESKAPE pathogens, with prime emphasis on the prevalence and risk factors for infections by multidrug-resistant (MDR) strains. Methodology: In this retrospective cohort study, we reviewed the electronic medical and laboratory records of our tertiary health-care facility throughout the period from January 2019 to December 2020. Adult patients identified with infections by any of the Gram-negative ESKAPE bacteria were eligible for our study. The risk factors associated with acquisition of MDR organisms were analyzed using univariate and multivariate models. Results: During the period of interest, a total of 614 Gram-negative ESKAPE isolates were identified, of which 121 were found to be MDR (19.7%). A. baumannii was the leading MDR organism (43.1%), whereas MDR P. aeruginosa was the least common (10.7%). The independent risk factors associated with acquisition of MDR infections included long hospital stays (P < 0.0001), undergoing surgical procedures (P= 0.001), ischemic heart disease (P= 0.005), mechanical ventilation (P= 0.005), and presence of indwelling urinary catheter (P= 0.03). Conclusions: Infections with MDR Gram-negative ESKAPE organisms have an alarming magnitude in our institution. Continued vigilance by the involved health-care workers, stringent compliance to the infection control guidelines, and effective implementation of the antimicrobial stewardship programs are critical measures to decrease the burden of this health problem.

DOI

10.21608/ejmm.2022.256008

Keywords

ESKAPE, pathogens, Antimicrobial, MDR, Gram-Negative, risk factors, ESBL

Authors

First Name

Rania

Last Name

El-Kady

MiddleName

-

Affiliation

Department of Medical Microbiology and Immunology, Faculty of Medicine, Mansoura University

Email

raniael_kady@yahoo.com

City

-

Orcid

-

First Name

Sara

Last Name

Karoma

MiddleName

-

Affiliation

Fakeeh College for Medical Sciences, Jeddah, KSA

Email

sarakaroma98@gmail.com

City

Jeddah

Orcid

-

First Name

Ahmad

Last Name

Al Atrouni

MiddleName

-

Affiliation

Microbiology Laboratory, Dr. Soliman Fakeeh Hospital, Jeddah, Kingdom of Saudi Arabia

Email

alalatrouni@fakeeh.care

City

Jeddah

Orcid

-

Volume

31

Article Issue

3

Related Issue

35368

Issue Date

2022-07-01

Receive Date

2022-08-23

Publish Date

2022-07-01

Page Start

135

Page End

142

Print ISSN

1110-2179

Online ISSN

2537-0979

Article File

EJMM_Volume 31_Issue 3_Pages 135-142.pdf

PDF . 395.6kB

Link

https://ejmm.journals.ekb.eg/article_256008.html

Detail API

https://ejmm.journals.ekb.eg/service?article_code=256008

Order

256,008

Type

New and original researches in the field of Microbiology.

Type Code

2,038

Publication Type

Journal

Publication Title

Egyptian Journal of Medical Microbiology

Publication Link

https://ejmm.journals.ekb.eg/

MainTitle

Multidrug-Resistant Gram-Negative ESKAPE Pathogens from a Tertiary-Care Hospital: Prevalence and Risk Factors

Details

Type

Article

Created At

23 Jan 2023