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249267

Fungal Coinfections in COVID-19-Positive Patients at a Tertiary Care Hospital in Saudi Arabia

Article

Last updated: 28 Dec 2024

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Subjects

-

Tags

Clinical microbiology

Abstract

Background: Most coronavirus disease 2019 (COVID-19) patients present with mild or moderate severity of the disease. However, disease comorbidities may require mechanical ventilation and intensive care (IC), which predispose COVID-19 patients to secondary opportunistic fungal infections.  Objective: An observational retrospective cohort study was conducted to investigate the relationship between fungal coinfections and morbidity and mortality rates in patients with severe COVID-19 admitted to a tertiary hospital in Makkah, Saudi Arabia. Methodology: This work was conducted on 1,220 patients with COVID-19 admitted to a Saudi Tertiary Care Hospital in Makkah city from June 1, 2020, to May 30, 2021, to evaluate the existence of fungal infections. COVID-19 cases were confirmed by real-time reverse transcription-polymerase chain reaction (RT-PCR). Statistical analysis was performed via SPSS version 22.0 (IBM, USA). Results: Of the 1,220 included samples, fungal coinfections were detected in 57 (4.7%) patients. Candida albicans was the major isolated strain in 39 (68.4%) patients, and the primary source of infection was sputum (40 patients: 70.2%). Most samples were isolated from the ICU (41 patients; 71.9%); bacteria coinfection was detected in 12 (21%) severely ill patients. Conclusion: Mindfulness of the plausibility of fungal coinfection is important to control infection and ultimately reduces the risk and the delay in diagnostic and treatment process. It will also guide the diagnostic tools in identifying high-risk patients and quickly determine the most appropriate interventions for reducing the possibility of infection besides morbidity and mortality rates.

DOI

10.21608/ejmm.2022.249267

Keywords

COVID-19, SARS-CoV-2, fungal coinfections

Authors

First Name

Abdelrahman

Last Name

Elsawy

MiddleName

-

Affiliation

Department of Medical Microbiology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt

Email

-

City

-

Orcid

-

First Name

Khalid

Last Name

Al-Quthami

MiddleName

-

Affiliation

Department of Medical Microbiology, Alnoor Specialist Hospital, Makkah, Kingdom of Saudi Arabia

Email

-

City

-

Orcid

-

First Name

Hamdi

Last Name

Al-Said

MiddleName

Mustafa

Affiliation

Department of Microbiology, Faculty of Medicine, Umm Al-Qura

Email

hamdimustafa1@gmail.com

City

-

Orcid

-

First Name

Reem

Last Name

Allam

MiddleName

-

Affiliation

Department of Clinical Pathology, Faculty of Medicine, Zagazig University, Egypt

Email

-

City

-

Orcid

-

First Name

Abdulmoin

Last Name

Al-Qarni

MiddleName

-

Affiliation

Department of Infectious disease, Alnoor Specialist Hospital, Makkah, Kingdom of Saudi Arabia

Email

-

City

-

Orcid

-

First Name

Mohammed

Last Name

Shaikh

MiddleName

-

Affiliation

Department of internal medicine, Alnoor Specialist Hospital, Makkah, Kingdom of Saudi Arabia

Email

-

City

-

Orcid

-

First Name

Yahya

Last Name

Alzahrani

MiddleName

-

Affiliation

Department of internal medicine, Alnoor Specialist Hospital, Makkah, Kingdom of Saudi Arabia

Email

-

City

-

Orcid

-

First Name

Hind

Last Name

Khan

MiddleName

-

Affiliation

Department of Medical Microbiology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt

Email

-

City

-

Orcid

-

First Name

Mawada

Last Name

Al-Kashkari

MiddleName

-

Affiliation

Department of Medical Microbiology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt

Email

-

City

-

Orcid

-

Volume

31

Article Issue

3

Related Issue

35368

Issue Date

2022-07-01

Receive Date

2022-07-14

Publish Date

2022-07-01

Page Start

91

Page End

97

Print ISSN

1110-2179

Online ISSN

2537-0979

Article File

EJMM_Volume 31_Issue 3_Pages 91-97.pdf

PDF . 268.8kB

Link

https://ejmm.journals.ekb.eg/article_249267.html

Detail API

https://ejmm.journals.ekb.eg/service?article_code=249267

Order

249,267

Type

New and original researches in the field of Microbiology.

Type Code

2,038

Publication Type

Journal

Publication Title

Egyptian Journal of Medical Microbiology

Publication Link

https://ejmm.journals.ekb.eg/

MainTitle

Fungal Coinfections in COVID-19-Positive Patients at a Tertiary Care Hospital in Saudi Arabia

Details

Type

Article

Created At

23 Jan 2023