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Macrophage Secretory Function among Urinary Tract Infection Patients before and after Ciprofloxacin Treatment: A Prospective Study

Article

Last updated: 05 Jan 2025

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-

Tags

Antimicrobial agents

Abstract

Background: Attacks of Urinary tract infections (UTIs) reached about 150 million patients every year worldwide. They are considered a major reason for morbidity in females in all age groups, older men and young boys. Objectives: To investigate the effect of Ciprofloxacin treatment during urinary tract infection (UTI) infection on the proinflammatory cytokines secretion including IL-1, IL-6, IL-10, IL-12, and TNF in the adult patients. Methodology: This prospective, observational cohort study involved 50 patients diagnosed with UTI over a period of 3 months from January to March 2019. On the day of admission (before starting ciprofloxacin treatment), all the UTI patients were submitted to an estimation of urine levels of proinflammatory cytokines including IL-1, IL-6, IL-12, IL-10, and TNF during the first 48 hours after hospital admission. Cytokine levels were estimated by enzyme-linked immunoassay (ELISA) kits (R&D Systems, Inc., Minneapolis, Minnesota, USA). The patients were treated with ciprofloxacin 500mg for 3 days. After 5 days of ciprofloxacin treatment course, the patient underwent remeasurement of urine level of cytokines. Results: After the fifth day of ciprofloxacin treatment course, it has been observed that there were significant decreases regarding proinflammatory cytokine TNF, IL1, and IL6. On the other hand, there was a significant increase in IL10 levels in the study cohort. Besides, there was no significant difference between before and after ciprofloxacin treatment regarding IL12 levels (P-value = 0.06). Conclusion: Ciprofloxacin treatment significantly reduces the levels of the proinflammatory cytokine in patients with UTIs.

DOI

10.21608/ejmm.2022.247204

Keywords

Proinflammatory cytokines, Urinary tract infection, ciprofloxacin, Prospective study

Authors

First Name

Mahmoud

Last Name

El-Ansary

MiddleName

-

Affiliation

Department of Immunology and Medical Microbiology, Faculty of Medicine, Misr University for Science and Technology, Giza, Egypt

Email

melansary2022@gmail.com

City

-

Orcid

0000-0003-2458-1930

Volume

31

Article Issue

3

Related Issue

35368

Issue Date

2022-07-01

Receive Date

2022-07-01

Publish Date

2022-07-01

Page Start

57

Page End

61

Print ISSN

1110-2179

Online ISSN

2537-0979

Article File

EJMM_Volume 31_Issue 3_Pages 57-61.pdf

PDF . 338.7kB

Link

https://ejmm.journals.ekb.eg/article_247204.html

Detail API

https://ejmm.journals.ekb.eg/service?article_code=247204

Order

247,204

Type

New and original researches in the field of Microbiology.

Type Code

2,038

Publication Type

Journal

Publication Title

Egyptian Journal of Medical Microbiology

Publication Link

https://ejmm.journals.ekb.eg/

MainTitle

Macrophage Secretory Function among Urinary Tract Infection Patients before and after Ciprofloxacin Treatment: A Prospective Study

Details

Type

Article

Created At

23 Jan 2023