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247182

HLA DRB1 alleles in association with acute and chronic myeloid leukemia and evaluation of their role as markers for selection of the line of treatment

Article

Last updated: 05 Jan 2025

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Subjects

-

Tags

Genetics

Abstract

Background: The genes that encode the human leukocyte antigens (HLA) molecules are the most polymorphic in the human genome and have been considered as possible genetic risk factor in the development of acute and chronic leukemias. Objective: This study aimed at evaluating the role of HLA DRB1 alleles as markers for selection of the line of therapy in Acute myeloid leukemia (AML) and Chronic myeloid leukemia (CML) patients. Methodology: The study was conducted on: 20 AML, 20 CML cases and 20 healthy controls. Typing was done by the sequence-specific primer (PCR-SSP). Results: There was a highly statistical significance association between response to treatment and HLA DRB1 alleles as markers (MCP= .0001) in AML and CML patients. The HLA-DRB1 04*04 allele was found to be associated with good response to therapy in AML patients while, HLA-DRB1 07*15 allele was associated with bad response. In CML patients, HLA-DRB1 03*11 allele was found to be associated with good response to therapy while, HLA-DRB1 alleles 03*04 and 11*15 alleles were equally associated with bad response. Conclusion: Future researches are mandatory especially on larger scale to confirm whether these alleles are protective or even risk alleles regarding both AML and CML.

DOI

10.21608/ejmm.2022.247182

Keywords

AML, CML, HLA-DRB1 typing

Authors

First Name

Mona

Last Name

Morsi

MiddleName

-

Affiliation

Medical Microbiology and Immunology Department, Faculty of Medicine, University of Alexandria, Egypt

Email

morsirg@gmail.com

City

Alexandria

Orcid

-

First Name

Maha

Last Name

Elgharbawy

MiddleName

-

Affiliation

Medical microbiology and immunology department, Faculty of medicine, Alexandria university

Email

maha.elgharbawy@gmail.com

City

-

Orcid

-

First Name

Nahla

Last Name

Hamed

MiddleName

-

Affiliation

Hematology department, faculty of medicine, Alexandria university, Egypt

Email

nahla.hamed@alexmed.edu.eg

City

-

Orcid

-

First Name

Haidy

Last Name

Mamdouh

MiddleName

-

Affiliation

Medical microbiology and immunology department, Faculty of medicine, Alexandria university

Email

dodzi_128@hotmail.com

City

-

Orcid

-

First Name

Shams

Last Name

Arafa

MiddleName

Abd elfattah

Affiliation

Medical microbiology and immunology, faculty of medicine, Alexandria university

Email

shams.arafa@alexmed.edu.eg

City

Alexandria

Orcid

0000-0002-9683-4530

Volume

31

Article Issue

3

Related Issue

35368

Issue Date

2022-07-01

Receive Date

2022-07-01

Publish Date

2022-07-01

Page Start

37

Page End

42

Print ISSN

1110-2179

Online ISSN

2537-0979

Article File

EJMM_Volume 31_Issue 3_Pages 37-42.pdf

PDF . 360.3kB

Link

https://ejmm.journals.ekb.eg/article_247182.html

Detail API

https://ejmm.journals.ekb.eg/service?article_code=247182

Order

247,182

Type

New and original researches in the field of Microbiology.

Type Code

2,038

Publication Type

Journal

Publication Title

Egyptian Journal of Medical Microbiology

Publication Link

https://ejmm.journals.ekb.eg/

MainTitle

HLA DRB1 alleles in association with acute and chronic myeloid leukemia and evaluation of their role as markers for selection of the line of treatment

Details

Type

Article

Created At

23 Jan 2023