Beta
ManageSearchChatDiscover
229672

An Updated Outline of Klebsiella pneumoniae Resistance: Mechanisms and Treatments

Article

Last updated: 28 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

Clinical microbiology

Abstract

Klebsiella pneumoniae (K. pneumoniae) is the most prominent type of Klebsiella spp. K. pneumoniae has become a worldwide health threat nowadays due to the emergence of hypervirulence and the extended-spectrum β-lactamases (ESBLs) producing strains that lead to the etiologies of hospital-acquired infections (HAI) and community-acquired infections (CAI).  To survive within the host, the bacterium acquires virulence traits and techniques to resist antibiotics and the immune system response, hence it gradually becomes multidrug-resistant (MDR). Consequently, more antibiotics are rendered ineffective and thus inappropriate, causing more deteriorating clinical conditions, leading to a high mortality rate. While the vaccine of K. pneumoniae is still in progress, and since we are long past the beginning of antibiotic use, new concepts came to play to fight the bacterial infection such as the use of bacteriophage to destroy the prokaryotic cell and enhancement of the immune system.  This article covers the most common genetic and structural mechanisms of resistance by which K. pneumoniae exhibits its resilience against the defense system and various antibiotics. It also reviews the epidemiology, the leading sites of infections, and possible treatment options for future use.        

DOI

10.21608/ejmm.2022.229672

Keywords

K. pneumoniae, resistance mechanisms, phage therapy

Authors

First Name

Antony

Last Name

Soliman

MiddleName

Sameh

Affiliation

Pharmacy and Pharmaceutical Sciences, Ahram Canadian University (ACU), 6th October, Egypt.

Email

antonysoliman321@gmail.com

City

-

Orcid

-

First Name

Michael

Last Name

Agban

MiddleName

Nazmy

Affiliation

Microbiology and Immunology, Faculty of medicine, Assiut university, Egypt.

Email

agbanmichael@aun.edu.eg

City

-

Orcid

-

Volume

31

Article Issue

2

Related Issue

32749

Issue Date

2022-04-01

Receive Date

2022-03-26

Publish Date

2022-04-07

Page Start

127

Page End

136

Print ISSN

1110-2179

Online ISSN

2537-0979

Article File

EJMM_Volume 31_Issue 2_Pages 127-136.pdf

PDF . 733.0kB

Link

https://ejmm.journals.ekb.eg/article_229672.html

Detail API

https://ejmm.journals.ekb.eg/service?article_code=229672

Order

20

Type

Review articles

Type Code

2,039

Publication Type

Journal

Publication Title

Egyptian Journal of Medical Microbiology

Publication Link

https://ejmm.journals.ekb.eg/

MainTitle

An Updated Outline of Klebsiella pneumoniae Resistance: Mechanisms and Treatments

Details

Type

Article

Created At

23 Jan 2023