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228829

Characterization of Non- Fermenter Gram- Negative Bacilli infection in Intensive Care Unit of National Liver Institute

Article

Last updated: 05 Jan 2025

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Subjects

-

Tags

Clinical microbiology

Abstract

Background: Bacilli infections is a leading cause of mortality and morbidity for patients with cirrhosis especially with ICU hospitalization and overuse of antibiotics all complicate patient's prognosis. NFGNB are heterogenous group of gram -negative bacilli that emerged as hospital acquired pathogens. Objectives: To characterize non -fermenter gram negative bacilli isolated from different clinical specimen of the ICU admitted hepatic patients and assess if hospital environment and workers share in its spread. Methodology: This is a cross sectional observational study done on liver disease patients admitted to The National Liver Institute, Menoufia University, included ICU environmental samples and HCWs samples, where samples for bacteriological cultures were collected and cultivated by ordinary methods and Organisms were identified by biochemical and confirmed by VITEK 2 system. Antibiotic Resistance pattern was confirmed by automated system, E-test. Results were tabulated and analyzed. Results: NFGNB infection was prevalent among ICU hospitalized end stage liver disease patients representing (27.4%), environmental samples group which represent (12.5.5%) and HCWs group which represent (7.5%). Of which pseudomonas aeruginosa, Acinetobacter baumannii in patient samples were significantly higher than other groups. Higher percentage of MDR-NFGN and XDR-NFGN were predominant among isolates from all groups, but all are Colistin sensitive. Higher incidence of ESBLs producer NFGNB include Achromobacter xylosoxidans and Aeromonas hydrophila isolate as they represent (100%) followed by Burkholderia cepacia which represent (66.7%) while the highest incidence of MBL positive test were among Achromobacter xylosoxidans and Aeromonas hydrophila isolates followed by pseudomonas. E-test remains the golden test in detection of ESBL and MBL-NFGN. Conclusion: Resistant NFGNB is an emerging bacterium that threats hepatic patients 'outcome, especially pseudomonas aeruginosa, Acinetobacter baumannii at the front position for more studies regarding different patterns of antibiotic resistance in ICU. 

DOI

10.21608/ejmm.2022.228829

Keywords

NFGNB, ICU, hepatic patients, resistance

Authors

First Name

Enas

Last Name

Ghoneim

MiddleName

Mohamed

Affiliation

1Professor of Medical Microbiology and Immunology and head of Clinical Microbiology and Immunology department, National Liver Institute, Menoufia University, Shebin El-kom 32511, Egypt

Email

enas.ghonaim@liver.menofia.edu.eg

City

Shebin El-kom

Orcid

-

First Name

Tawfik

Last Name

Abed El motaleb

MiddleName

Mohamed

Affiliation

Professor of Medical Microbiology and Immunology, Clinical Microbiology and Immunology department, National Liver Institute, Menoufia University, Shebin El-kom 32511, Egypt,

Email

tawfeek.mohamed@liver.menofia.edu.eg

City

Shebin elkom

Orcid

-

First Name

Islam

Last Name

Elsheikh

MiddleName

Mohamed

Affiliation

Infection control specialist, Infection control department, Directorate of Health Affairs, Ministry of Health Shebin El-kom , Egypt

Email

alislam125@gmail.com

City

Shebin El-kom

Orcid

-

First Name

fatma

Last Name

khalil

MiddleName

o

Affiliation

Microbiology nd Immunology, National Liver Institute, Menoufia University, Shebin El-kom, Egypt

Email

fatma.khalil@liver.menofia.edu.eg

City

shebin el-kom

Orcid

0000-0002-3157-5232

Volume

31

Article Issue

2

Related Issue

32749

Issue Date

2022-04-01

Receive Date

2022-03-09

Publish Date

2022-04-03

Page Start

85

Page End

94

Print ISSN

1110-2179

Online ISSN

2537-0979

Article File

EJMM_Volume 31_Issue 2_Pages 85-94.pdf

PDF . 490.7kB

Link

https://ejmm.journals.ekb.eg/article_228829.html

Detail API

https://ejmm.journals.ekb.eg/service?article_code=228829

Order

14

Type

New and original researches in the field of Microbiology.

Type Code

2,038

Publication Type

Journal

Publication Title

Egyptian Journal of Medical Microbiology

Publication Link

https://ejmm.journals.ekb.eg/

MainTitle

Characterization of Non- Fermenter Gram- Negative Bacilli infection in Intensive Care Unit of National Liver Institute

Details

Type

Article

Created At

23 Jan 2023