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228622

Immunoglobulins Level in Patients Suffering from Major Depressive Disorder (MDD) in Comparison with Normal Healthy Individuals: A Prospective Study

Article

Last updated: 28 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

Clinical microbiology

Abstract

Background: Previous studies demonstrated significant elevations of immunoglobulin levels in various psychiatric disorders, however, no enough data is present regarding this association with major depressive disorder (MDD). Objectives: To compare the serum levels of immunoglobulins in individuals with MDD to healthy control persons. Methodology: We included 70 participants divided into two groups including 35 MDD patients with MDD from the Psychiatry Outpatient Clinic at Misr University of Science and Technology Hospital and 35 healthy controls. The sera were investigated for the level of total IgA, IgD, IgM, and IgG using enzyme-linked immunosorbent assay (ELISA) ImuPro 50 test. Results: Mean age of the 35 MDD patients was 32 years old while the normal individuals were aged 31 (P=0.621). The study revealed substantially lower levels of IgG, IgM, and IgA in depressed patients compared to controls. On the other hand, there was a significantly higher concentration of IgE and IgD in MDD patients than in controls. Conclusion: Immunoglobulin levels in the blood were found to be significantly linked to MDD. However, Future research should be the logical forward step in order to improve the quality of data about the importance of immunoglobulin levels in MDD patients.

DOI

10.21608/ejmm.2022.228622

Keywords

major depressive disorder, immunoglobulin, Prospective study

Authors

First Name

Mahmoud

Last Name

El-Ansary

MiddleName

-

Affiliation

Department of Immunology and Medical Microbiology, Faculty of Medicine, Misr University for Science and Technology, Giza, Egypt

Email

melansary2022@gmail.com

City

-

Orcid

0000-0003-2458-1930

First Name

Hossam

Last Name

El-Khatib

MiddleName

-

Affiliation

Department of Psychiatry, Faculty of Medicine, Misr University for Science and Technology, Giza, Egypt.

Email

hossamelkhateeb@hotmail.com

City

-

Orcid

0000-0003-0143-1999

Volume

31

Article Issue

2

Related Issue

32749

Issue Date

2022-04-01

Receive Date

2022-02-19

Publish Date

2022-04-01

Page Start

45

Page End

48

Print ISSN

1110-2179

Online ISSN

2537-0979

Article File

EJMM_Volume 31_Issue 2_Pages 45-48.pdf

PDF . 181.2kB

Link

https://ejmm.journals.ekb.eg/article_228622.html

Detail API

https://ejmm.journals.ekb.eg/service?article_code=228622

Order

8

Type

New and original researches in the field of Microbiology.

Type Code

2,038

Publication Type

Journal

Publication Title

Egyptian Journal of Medical Microbiology

Publication Link

https://ejmm.journals.ekb.eg/

MainTitle

Immunoglobulins Level in Patients Suffering from Major Depressive Disorder (MDD) in Comparison with Normal Healthy Individuals: A Prospective Study

Details

Type

Article

Created At

23 Jan 2023