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228615

Prevalence of Helicobacter pylori Infection in Patients with Primary Open Angle Glaucoma

Article

Last updated: 05 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

Pathogenicity and virulence

Abstract

Background: Primary Open-Angle Glaucoma (POAG) the most common form of glaucoma is a neurodegenerative disease, which is the third most common cause of blindness worldwide. Among the various factors that have been implicated in the pathophysiology of this disease is infection with Helicobacter pylori (HP), a Gram-negative bacterium that is commonly found in stomach and present in approximately one-half of the world's population. This association has caused a great deal of scientific discussion during the past decades, as the establishment of such a correlation might lead to therapeutic applications for all glaucoma patients. Objective: to determine the prevalence of Helicobacter pylori (H. pylori) infection in the primary open angle glaucoma (POAG) in Egyptian cohort. Methodology: Peripheral venous blood samples were withdrawn from each participant and tested for existence of H. pylori particular immunoglobulin G antibodies by enzyme-linked immunosorbent assay in 63 cases with POAG as well as from aged matched non glaucomatous controls at the glaucoma subspecialty Clinic at the Research Institute of Ophthalmology, Giza, Egypt. Results: 63 patients (71.4% (45 cases) of them were females with POAG and 30 healthy controls (70% (11 cases) were females and were recruited in our study. Mean age was 57 for POAG patients and 46 for controls. Helicobacter pylori antibodies G were found reactive using ELISA technique in 52 out of 63 patients for POAG group (82.5%) and 13 out of 30 healthy controls (43.3%). Conclusion: High association could be reported between H. pylori and primary open-angle glaucoma suggesting a potential correlation between both.

DOI

10.21608/ejmm.2022.228615

Keywords

Helicobacter pylori infection, Immunoglobulin G, Primary open-angle glaucoma

Authors

First Name

Mai

Last Name

Alkaffas

MiddleName

-

Affiliation

Department of Medical Microbiology and Immunology, Research of Institute of Opthalmology, Giza, Egypt

Email

kaffas_mai@hotmail.com

City

-

Orcid

-

First Name

Amr

Last Name

Aref

MiddleName

-

Affiliation

Researcher, Department of Glaucoma, Research Institute of Ophthalmology, Giza, Egypt

Email

faress80@yahoo.com

City

-

Orcid

-

Volume

31

Article Issue

2

Related Issue

32749

Issue Date

2022-04-01

Receive Date

2022-01-26

Publish Date

2022-04-01

Page Start

19

Page End

22

Print ISSN

1110-2179

Online ISSN

2537-0979

Article File

EJMM_Volume 31_Issue 2_Pages 19-22.pdf

PDF . 215.2kB

Link

https://ejmm.journals.ekb.eg/article_228615.html

Detail API

https://ejmm.journals.ekb.eg/service?article_code=228615

Order

4

Type

New and original researches in the field of Microbiology.

Type Code

2,038

Publication Type

Journal

Publication Title

Egyptian Journal of Medical Microbiology

Publication Link

https://ejmm.journals.ekb.eg/

MainTitle

Prevalence of Helicobacter pylori Infection in Patients with Primary Open Angle Glaucoma

Details

Type

Article

Created At

23 Jan 2023