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211954

Assessment of In vitro Activities of Ceftaroline, Ceftazidime/ avibactam and Colistin against different Gram Negative and Gram Positive Isolates

Article

Last updated: 28 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

Antimicrobial agents

Abstract

Background: Multidrug resistance organisms (MDRO) emergence is recognized as a serious threat to worldwide health and welfare. Infections with MDRO are associated with longer hospitalization periods, relatively high infection-related death, and greater health expenditures. The appearance of carbapenems resistant Enterobacteriaceae (CRE) and vancomycin resistant Staph aureus (VRS) makes the condition worse, since carbapenems and vancomycin were the drug of choice in treatment of MDR Enterobacteriaceae and methicillin resistant Staph aureus (MRSA). Accordingly the evaluation of new drugs used as substitution to other resistant antibiotics became an urgent need worldwide. Objective: The objective of this research is to assess the in vitro activity of ceftaroline, ceftazidime-avibactam and colistin activity against various complicated infections with resistant bacteria. Methodology: Antibiotic susceptibility of all clinical isolates was performed by the disk diffusion method, and results in interpretation were performed according to CLSI guidelines (2019) Results: concerning Gram-negative bacteria, ceftazidime-avibactam and colistin showed high susceptibility (>85%) and (100%) respectively against Pseudomonas aeruginosa and Enterobacteriaceae, with enhanced antibacterial activity due to the inclusion of avibactam to ceftazidime drug. Ceftaroline demonstrated susceptibility ranged from (53% - 75.8%) against Gram-negative bacteria and (> 75%) against Gram-positive bacteria including MRSA. Conclusion: results showed acceptable susceptibility of both Gram negative and Gram positive isolates against tested antibiotics, however further investigations on increased number of isolates are required. 

DOI

10.21608/ejmm.2022.211954

Keywords

multidrug resistance, Carbapenem Resistant Enterobacteriaceae, methicillin resistant Staph aureus

Authors

First Name

Mona

Last Name

Nour

MiddleName

S.

Affiliation

Assistant Professor, Department of Medical Microbiology and Immunology, Faculty of Medicine, Ain Shams University, Cairo, Egypt

Email

d.monasaad@gmail.com

City

-

Orcid

-

First Name

Mai

Last Name

Al-Kaffas

MiddleName

-

Affiliation

Department of Medical Microbiology and Immunology, Research of Institute of Ophthalmology, Giza, Egypt

Email

kaffas_mai@hotmail.com

City

Cairo

Orcid

-

Volume

31

Article Issue

1

Related Issue

29807

Issue Date

2022-01-01

Receive Date

2021-11-21

Publish Date

2022-01-01

Page Start

55

Page End

62

Print ISSN

1110-2179

Online ISSN

2537-0979

Article File

EJMM_Volume 31_Issue 1_Pages 55-62.pdf

PDF . 263.4kB

Link

https://ejmm.journals.ekb.eg/article_211954.html

Detail API

https://ejmm.journals.ekb.eg/service?article_code=211954

Order

8

Type

New and original researches in the field of Microbiology.

Type Code

2,038

Publication Type

Journal

Publication Title

Egyptian Journal of Medical Microbiology

Publication Link

https://ejmm.journals.ekb.eg/

MainTitle

Assessment of In vitro Activities of Ceftaroline, Ceftazidime/ avibactam and Colistin against different Gram Negative and Gram Positive Isolates

Details

Type

Article

Created At

23 Jan 2023