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211936

Prevalence of Human Papilloma Virus and Adeno-associated Virus in Semen of Infertile Undergoing Assisted Reproduction

Article

Last updated: 28 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

Diagnostics

Abstract

Background: HPV and AAV infection are suggested to be a risk factor for infertility in men. Objective: To detect the prevalence of human papilloma virus (HPV) and adeno associated virus (AAV) in semen of men suffering from infertility. Methodology: One hundred and thirty-eight Egyptian men were included in the study, 69 infertile patients and 69 fertile men. Conventional PCR was done for HPV genome determination, and nested PCR for AAV detection from the semen samples. Results: 23.2% infertile men samples were containing virus, compared with 4.3% positive semen samples among fertile men with a significant difference. Among infertile patients, 10.1% of the samples had HPV genome, 8.7% had AAV and 4.3% showed co-infection with both viruses. Regarding semen parameters, 52.2% of infertile patients showed normal parameters, 47.8% showed asthenozoospermia, oligoasthenoteratozoospermia (OAT) in 33.3%, oligoasthenospermia (OA) in 27.3 %, and oligozoospermia in 6.1%. All infertile patients underwent ICSI, neither of HPV, AAV or co-infection affected the success rate. Out of 16 patients positive for viral infection, 9 (56.3%) showed successful ICSI and 7 patients (43.8%) had failed outcome with nonsignificant difference. Conclusions: HPV and AAV must be excluded in male infertility, due to their high prevalence among this group with negative effects on semen parameters. 

DOI

10.21608/ejmm.2022.211936

Keywords

Male infertility, Semen, HPV, AAV, ICSI

Authors

First Name

Nouran

Last Name

Samra

MiddleName

E

Affiliation

Microbiology and Immunology Department, Faculty of Medicine, Mansoura University

Email

drnouransamra@mans.edu.eg

City

-

Orcid

-

First Name

Wafaa

Last Name

Mowafy

MiddleName

K.

Affiliation

Microbiology and Immunology Department, Faculty of Medicine, Mansoura University

Email

microdepnetwork@gmail.com

City

-

Orcid

-

First Name

Ibrahim

Last Name

Abdel-Hamid

MiddleName

A.

Affiliation

Division of Andrology, Faculty of Medicine, Mansoura University

Email

-

City

-

Orcid

-

First Name

Mohamed

Last Name

Ghanem

MiddleName

E.

Affiliation

Mansoura Integrated Fertility Centre, Mansoura, Egypt

Email

-

City

-

Orcid

-

First Name

Doaa

Last Name

Masallat

MiddleName

Tawfik

Affiliation

Department of Microbiology and Immunology, Faculty of Medicine, Mansoura University

Email

doaamasallat@yahoo.com

City

Mansoura

Orcid

0000-0002-3856-7999

Volume

31

Article Issue

1

Related Issue

29807

Issue Date

2022-01-01

Receive Date

2021-11-15

Publish Date

2022-01-01

Page Start

31

Page End

37

Print ISSN

1110-2179

Online ISSN

2537-0979

Article File

EJMM_Volume 31_Issue 1_Pages 31-37.pdf

PDF . 412.0kB

Link

https://ejmm.journals.ekb.eg/article_211936.html

Detail API

https://ejmm.journals.ekb.eg/service?article_code=211936

Order

5

Type

New and original researches in the field of Microbiology.

Type Code

2,038

Publication Type

Journal

Publication Title

Egyptian Journal of Medical Microbiology

Publication Link

https://ejmm.journals.ekb.eg/

MainTitle

Prevalence of Human Papilloma Virus and Adeno-associated Virus in Semen of Infertile Undergoing Assisted Reproduction

Details

Type

Article

Created At

23 Jan 2023