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211933

Diagnostic Value of Serum Level of Interleukin 33 (IL-33), C-C Motif Chemokine Ligand 17 (CCL17) and Interferon Gamma Inducible Protein-10 (IP-10) in Coronavirus Disease 2019 (CO

Article

Last updated: 28 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

Diagnostics

Abstract

Background: Coronavirus disease 2019 (COVID-19) has a diverse course; It seems to be asymptomatic or may produce mild symptoms which occurs in majority of the cases, however cytokine storm, macrophage activation syndrome (MAS), and acute respiratory distress syndrome (ARDS) could also happen as complications in some patients. Objective: This study aims to evaluate the serum level of IL-33, CCL17 and IP-10 in moderate and severe cases of COVID-19 and its diagnostic value. Methodology: IL-33, CCL17 and IP-10 were measured in the serum specimens of 40 cases of COVID-19, including 20 severe and 20 moderate patients, and compared with 20 healthy controls. Results: The values of IL-33, CCL17 and IP-10 were significantly higher in COVID-19 cases over than healthy controls. IL-33, CCL17 and IP-10 were excellent predictors for COVID-19, and the three cytokines together exhibited the greatest area under the curve (0.957). Conclusions: In this study, we report biomarkers that are highly associated with COVID-19 and can be used as diagnostic biomarkers. These findings aid to our understanding of the immunopathology of SARS CoV2 infection and provide potential targets and strategies for therapy.

DOI

10.21608/ejmm.2022.211933

Keywords

SARS CoV- 2, IL-33, CCL17, IP-10, Cytokine Storm, COVID-19

Authors

First Name

Nouran

Last Name

Moustafa

MiddleName

Magdy

Affiliation

Basic Medical Science Department, Faculty of Medicine, Dar Al Uloom University, Riyadh, Saudi Arabia

Email

nouran.m@dau.edu.sa

City

Riyadh, Saudi Arabia

Orcid

-

First Name

Rania

Last Name

Mohamed

MiddleName

A.

Affiliation

Medical Microbiology & Immunology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt

Email

-

City

-

Orcid

-

First Name

Rania

Last Name

Elsaid

MiddleName

G.

Affiliation

Anesthesia, Intensive Care and Pain Management Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt

Email

-

City

-

Orcid

-

First Name

Fatma

Last Name

Mahmoud

MiddleName

M.

Affiliation

Medical Microbiology & Immunology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt

Email

-

City

-

Orcid

-

Volume

31

Article Issue

1

Related Issue

29807

Issue Date

2022-01-01

Receive Date

2021-10-30

Publish Date

2022-01-01

Page Start

23

Page End

30

Print ISSN

1110-2179

Online ISSN

2537-0979

Article File

EJMM_Volume 31_Issue 1_Pages 23-30.pdf

PDF . 503.1kB

Link

https://ejmm.journals.ekb.eg/article_211933.html

Detail API

https://ejmm.journals.ekb.eg/service?article_code=211933

Order

4

Type

New and original researches in the field of Microbiology.

Type Code

2,038

Publication Type

Journal

Publication Title

Egyptian Journal of Medical Microbiology

Publication Link

https://ejmm.journals.ekb.eg/

MainTitle

Diagnostic Value of Serum Level of Interleukin 33 (IL-33), C-C Motif Chemokine Ligand 17 (CCL17) and Interferon Gamma Inducible Protein-10 (IP-10) in Coronavirus Disease 2019 (COVID-19) Patients

Details

Type

Article

Created At

23 Jan 2023