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Correlation of Serum Levels of Interleukin‑1β and CCL 24 with Severity of Persistent Allergic Rhinitis in Children

Article

Last updated: 28 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

Clinical microbiology

Abstract

Background: Allergic rhinitis (AR) is a distressing clinical presentation especially in pediatric age which affects quality of life and may predispose to bronchial asthma. Various inflammatory biomarkers might be involved in allergic rhinitis pathogenesis and correlated with its severity such as IL1 β and CCL 24. Objectives: This study aims to detect serum level of IL 1 β and CCL24 in studied pediatric patients and correlate their levels with the severity of allergic rhinitis and with comorbid asthma in children. Methodology: Peripheral bloodeosinophil count was detected andserum level of IgE, IL1 β and CCL24 were assayed in pediatric patients with allergic rhinitis using ELISA. In addition, correlation of their levels with the severity of AR. Results: Eosinophil count and serum levels of IL1 β and CCL24 were significantly elevated in (AR) patients compared with the controls (P=0.00001*), (P=0.026*) and (P=0.017*) respectively. Parental smoking and Associated Asthma of high statistical significance when correlated with severity of allergic rhinitis (P=0.005) and (P<0.001) respectively. Family history of allergy& allergy in other sibling were also significantly correlated with severity of AR (P=0.093) and (P=0.02) respectively. Conclusion: This study clarifies the evidence that IL-1β is an important inflammatory biomarker for pathogenesis and severity of allergic rhinitis and it might predispose to other allergic diseases subsequently it may be investigated as a therapeutic target especially in severe cases.

DOI

10.21608/ejmm.2022.211920

Keywords

IL-1β, CCL24, Allergic Rhinitis and Children

Authors

First Name

Alshimaa

Last Name

Abdallah

MiddleName

L.

Affiliation

Lecturer of Medical Microbiology and Immunology, Faculty of Medicine, Zagazig University, Egypt.

Email

drshimo82@yahoo.com

City

Zagazig

Orcid

-

First Name

Hanaa

Last Name

El Maghraby

MiddleName

M.

Affiliation

Otolaryngology Department, Faculty of Medicine, Zagazig University, Egypt

Email

dr_hm55@yahoo.com

City

-

Orcid

-

First Name

Mohamed

Last Name

El Gandy

MiddleName

S.

Affiliation

Otolaryngology Department, Faculty of Medicine, Zagazig University, Egypt

Email

drmoh-ent@yahoo.com

City

-

Orcid

-

First Name

Marwa

Last Name

Shabana

MiddleName

A.

Affiliation

Clinical Pathology Department, Faculty of Medicine - Zagazig University, Egypt

Email

marwa-shabana@yahoo.com

City

-

Orcid

-

First Name

Heba

Last Name

Mohammed

MiddleName

A.

Affiliation

Clinical Pathology Department, Faculty of Medicine - Zagazig University, Egypt

Email

hebadiab2005@gmail.com

City

-

Orcid

-

Volume

31

Article Issue

1

Related Issue

29807

Issue Date

2022-01-01

Receive Date

2021-10-23

Publish Date

2022-01-01

Page Start

1

Page End

6

Print ISSN

1110-2179

Online ISSN

2537-0979

Article File

EJMM_Volume 31_Issue 1_Pages 1-6.pdf

PDF . 341.3kB

Link

https://ejmm.journals.ekb.eg/article_211920.html

Detail API

https://ejmm.journals.ekb.eg/service?article_code=211920

Order

1

Type

New and original researches in the field of Microbiology.

Type Code

2,038

Publication Type

Journal

Publication Title

Egyptian Journal of Medical Microbiology

Publication Link

https://ejmm.journals.ekb.eg/

MainTitle

Correlation of Serum Levels of Interleukin‑1β and CCL 24 with Severity of Persistent Allergic Rhinitis in Children

Details

Type

Article

Created At

23 Jan 2023