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202209

Symbiotic effect of lactobacillus acidophilus, Ginger, Pineapple and Green Coffee in the complex management of obesity in rats

Article

Last updated: 28 Dec 2024

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Subjects

-

Tags

Antimicrobial agents

Abstract

Background: Obesity is a chronic metabolic disease associated with having excess body fat that could be influenced by many factors. Our study aimed to assess the powerful effect of Lactobacillus acidophilus alone or combined (symbiotic) with Prebiotic such as Ginger, Pineapple and Green Coffee as anti-obesity agents. Methodology: Using 8 groups (10 rats each) of Sprague-Dawley rats, Group 1 was kept as a negative control, Group 2 positive control, while other groups were orally given Lactobacillus acidophilus, Ginger, Pineapple and Green Coffee individually and in combination with Probiotics, for 45 days till the end of the experiment while the body weight of rats was recorded.Blood samples were collected for biochemical parameters analysis and organs were dissected and homogenized to analyze obesity-related biomarkers, Results: Our results revealed that either individual or mixed administration of this pro and prebiotics decreased the body and organs, specifically those treated with the mixture or probiotic and prebiotic, also serum (HDL), CAT), and (SOD) was decreased (P <0.05), while  other biochemical parameters (T.G), (CHOL), (U.A), (Creat), Urea, (GOT),(GPT) and (ALP); ( significantly (P<0.05) was decreased when compared with the positive control group, Nevertheless, the histopathological examination showed the reduction of adipose tissue in kidney, liver, and Pancreas showed overestimate reductions in the percentage of body fat. Conclusions: This study showed a promising effect of Lactobacillus acidophilus when it combined with these plants as natural feed additives on obesity.

Keywords

probiotics, Lactobacillus acidophilus, prebiotic, Ginger, pineapple, Green coffee

Authors

First Name

Dalia

Last Name

Elebeedy

MiddleName

-

Affiliation

College of Biotechnology, Misr University for Science and Technology (MUST), 6th of October City, Egypt

Email

dalia.elebeedy@must.edu.eg

City

Giza

Orcid

-

Volume

30

Article Issue

1

Related Issue

28170

Issue Date

2021-01-01

Receive Date

2020-11-02

Publish Date

2021-01-01

Page Start

143

Page End

152

Print ISSN

1110-2179

Online ISSN

2537-0979

Article File

EJMM_Volume 30_Issue 1_Pages 143-152.pdf

PDF . 1.1MB

Link

https://ejmm.journals.ekb.eg/article_202209.html

Detail API

https://ejmm.journals.ekb.eg/service?article_code=202209

Order

18

Type

New and original researches in the field of Microbiology.

Type Code

2,038

Publication Type

Journal

Publication Title

Egyptian Journal of Medical Microbiology

Publication Link

https://ejmm.journals.ekb.eg/

MainTitle

Symbiotic effect of lactobacillus acidophilus, Ginger, Pineapple and Green Coffee in the complex management of obesity in rats

Details

Type

Article

Created At

23 Jan 2023