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202199

Incidence, Causative Organisms and Pattern of Drug Resistance of Nosocomial Urinary Tract Infection in Patients with Liver Cirrhosis

Article

Last updated: 05 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

prevention of hospital infections

Abstract

Background: The nosocomial urinary tract infections (UTIs) creates a major health problem in hospitals all over the world. Objectives: We aimed in this study to determine the incidence of nosocomial UTIs in our cirrhotic patients, identification of the most common pathogens responsible for nosocomial UTIs and identification of the pattern of drug resistance. Methodology: 366 cirrhotic patients were studied within one year. Patients with apparent clinical manifestations of any UTI at time of admission were excluded. All patients were subjected to clinical evaluation, abdominal ultrasound examination, and laboratory investigations including complete blood picture, renal function tests, liver function tests and urine analysis at time of admission. Urine samples were collected from the infected patients for both bacterial and fungal cultures and drug sensitivity testing. Results: The frequency of nosocomial UTIs in cirrhotic patients was 7.1%.  The most significant risk factor was urinary catheterization (OR=189.0). Gram negative bacilli were the first cause (46%) of nosocomial urinary tract infection followed by fungi (36%). The sensitivity revealed that the most sensitive antibiotic for both Gram positive and Gram negative cocci was Gatifloxacin. The most sensitive antifungal for candida albicans was Nystatin. Conclusion: The frequency of nosocomial UTIs in cirrhotic patients was not low. Malnutrition and urinary catheterization were the most significant risk factors. Urinary fungal infection was not rare and must be in mind. Both bacterial and fungal cultures and their sensitivity to antibacterial and antifungal drugs were very important to improve the survival rate of patients.

Keywords

Cirrhosis, UTIs, Catheters, E. coli, Candida

Authors

First Name

Hebatallah

Last Name

Hassan

MiddleName

M.

Affiliation

Lecturer at Department of Medical Microbiology & Immunolgy, Assiut University, Assiut, Egypt

Email

heba.ismailhassan@gmail.com

City

Assiut

Orcid

-

Volume

30

Article Issue

1

Related Issue

28170

Issue Date

2021-01-01

Receive Date

2020-11-09

Publish Date

2021-01-01

Page Start

125

Page End

132

Print ISSN

1110-2179

Online ISSN

2537-0979

Article File

EJMM_Volume 30_Issue 1_Pages 125-132.pdf

PDF . 284.2kB

Link

https://ejmm.journals.ekb.eg/article_202199.html

Detail API

https://ejmm.journals.ekb.eg/service?article_code=202199

Order

16

Type

New and original researches in the field of Microbiology.

Type Code

2,038

Publication Type

Journal

Publication Title

Egyptian Journal of Medical Microbiology

Publication Link

https://ejmm.journals.ekb.eg/

MainTitle

Incidence, Causative Organisms and Pattern of Drug Resistance of Nosocomial Urinary Tract Infection in Patients with Liver Cirrhosis

Details

Type

Article

Created At

23 Jan 2023